Chymase inhibitor on pulmonary fibrosis in rats and its effects on angiotensinand its receptor.docVIP

 PAGE \* MERGEFORMAT 16 Chymase inhibitor on pulmonary fibrosis in rats and its effects on angiotensinand its receptor Of: Guyan Lan, Zhengjin Xu, Wan Bing, pipe Shu-hong [Abstract] Objective: To investigate chymase inhibitor (Chy I on bleomycin (BLM-induced pulmonary fibrosis model of intervention and its effect on angiotensin and its receptor, and to explore chymase in pulmonary fibrosis mechanism. Methods: 60 healthy SD rats were randomly divided into 3 groups: normal control group (saline, model group (bleomycin, the intervention group (bleomycin + chymase inhibitors. respectively at 7,14 , 21,28 days, 5 rats in each group HE staining to observe pathological changes in bronchopulmonary and immunohistochemistry in lung tissue angiotensin and its receptor expression. Results: (1 rating alveolitis: Intervention group and model group and control group, the difference was statistically significant, but the intervention group and model group difference was not statistically significant. (2 Evaluation of pulmonary fibrosis: intervention group and model group and control group were statistically meaning, and between the intervention group and model group, the difference also statistically significant. (3 angiotensin and its receptor expression analysis: model of interstitial lung vascular expression of angiotensin and its receptor are continuing enhanced intervention group was significantly reduced. Conclusion: The chymase inhibitors can reduce bleomycin-induced pulmonary fibrosis, probably by down and angiotensin type 1 receptor (AT1) expression in the works . [Keywords:] pulmonary fibrosis, chymase, angiotensin [Abstract] Objective: To study the effect of chymase inhibitor on bleomycin induced pulmonary fibrosis in rats and its possible mechanism. Methods: Sixty female rats were randomly divided into three groups: the model group, the control group and the chymase inhibitor treatment group, in which the rats were intratracheally instilled with (