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DNA repair complex DNA PK - cancer radiotherapy pharmacological target
PAGE \* MERGEFORMAT 24
DNA repair complex DNA PK - cancer radiotherapy pharmacological target
Keywords: DNA repair; DNA PK inhibitor; tumor; radiosensitizer
Present study the sensitivity of tumor cells to radiation, DNA repair protein inhibitor is a hot spot. In repairing DNA, proteins, DNA-dependent protein kinase (DNA PK) involved in multi-cellular organisms of non-homologous end joining (NHEJ) process, to protect due to ionizing radiation-induced double-stranded DNA damaged cells, so it specific inhibitors as radiation sensitizers drawn greater attention. In this paper, the mechanism of DNA damage repair and DNA PK inhibitor described the biological characteristics.
1 Overview
To improve the survival rate of cancer patients, should continue to select as small as possible side effects of a comprehensive treatment. Find effective in inhibiting DNA damage repair factors in order to apply to the radiosensitizer in, is the study of a hot spot. DNA damage triggers a variety of cell responses, including DNA, self-healing, approaches are reversed, remove or re-alignment, you can participate in a variety of ways. Research has shown that tumor cells are not sensitive to radiotherapy and its DNA repair activity highly. Accordingly, pharmaceutical companies have been embarking on the development of inhibitors of DNA repair.
But the DNA repair inhibitors can cause adverse reactions. Because of DNA repair is a normal physiological phenomenon of cell involved in the maintenance of genetic stability, its activity was inhibited can lead to mismatch repair or nucleotide excision repair capacity decline, triggering malignant normal tissue, therefore DNA repair activity as a drug Science must carefully target its repair mechanism and a key protein involved in response in order to help assess the potential side effects such as cell toxicity or cancer, and to design inhibitors of specificity.
Passing through in a vari
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