Erythromycin on rat model of chronic obstructive pulmonary disease airway inflammation.docVIP

 PAGE \* MERGEFORMAT 8 Erythromycin on rat model of chronic obstructive pulmonary disease airway inflammation [Abstract] Objective of erythromycin in chronic obstructive pulmonary disease (COPD) in the treatment of airway inflammatory. METHODS 24 Wistar rats were randomly divided into normal female control group, smoking group, erythromycin group, n = 8 only. erythromycin group were smokers and smoked joint by intratracheal instillation of lipopolysaccharide 1 month to establish COPD model. erythromycin group 1 month after the system model given erythromycin 100 mg / kg orally 1 months. application of rat pulmonary function pulmonary function test on each group of rats, and rat bronchial lavage fluid (BALF) cell count. by ELISA, serum levels of TNF-@, IL-8 content. Results smoking group compared with the normal forced expiratory volume occupied by 0.3 s vital capacity percentage (FEV0.3/FVC), dynamic compliance (Cdyn) decreased, inspiratory resistance (Ri), expiratory resistance (Re) increased; red mold hormone group and smoking group FEV0. 3 / FVC, Cdyn, Ri and Re were significantly improved (P lt;0.05). Smoking serum TNF-@, IL-8 levels compared with the normal group was significant difference (P lt; 0.001). Erythromycin serum levels of TNF-@, IL-8 levels compared with the smoking group also showed significant differences (P lt;0.001). smoking group and the total number of leukocytes in BALF neutrophils was significantly higher than the percentage of normal control (P lt;0.01), erythromycin group was significantly lower than smoking (P lt;0.05), compared with the control group but the total number of cells increased (P lt;0.01), percentage of neutrophils increased (P lt;0.05) . Conclusion erythromycin could partially reduce airway inflammation, which may be related to the inhibition of neutrophil accumulation and activation of inflammatory cells inhibited the secretion of TNF-@, IL-8 and other inflammatory mediators related. [Keywords:] erythromycin; ani