Esophageal epithelial dysplasia and early cancer preliminary study of serum markers.docVIP

 PAGE \* MERGEFORMAT 5 Esophageal epithelial dysplasia and early cancer preliminary study of serum markers Author: Liu Bin, Cui Jianfeng, Liu V, CHEN Wen, Chan Fung, Luehning, Pan Qin mirror, Wei-Qiang, Qiao Lin [Abstract] Objective To find a screening of precancerous lesions of esophageal squamous cell method, in order to provide the basis for early diagnosis of esophageal cancer. Lin City in Henan Province high incidence of esophageal cancer, the use of esophagoscopy and Lugol’s iodine staining of the screening study of 725 people. All of the subjects, taking tissue biopsy, and collect blood samples. By esophagoscopy histopathology were divided into normal, esophagitis, dysplasia, early cancer, 84 cases were randomly selected as a research object, part of the ELISA, the serum concentration of tumor molecular markers, including: metal matrix protein (MMP  9); tissue inhibitor (TIMP  1); Cu / Zn superoxide dismutase (Cu / Zn SOD); anti  p53 antibodies (Anti  p53auto  antibody) and soluble serum interleukin  2 receptor ( IL  2sRα ). The results of normal and esophagitis group of MMP  9 The median concentration of 150ng/ml, IQR of (80 ~ 225) ng / ml; dysplasia and early cancer group, median 97ng/ml, quarterback distance is (58 ~ 155) ng / ml; the concentration difference between the two groups was statistically significant (P = 0.033). The other four kinds of serum markers between the two groups was no significant difference. Conclusions MMP  9 detection of esophageal squamous dysplasia screening of some significance, but needs further study. [Keywords:] Esophageal neoplasms; precancerous lesions; cross-sectional survey; serum markers Serum Markers as Predictors of Esophageal Squamous Dysplasia and Early Cancer Keywords:: Esophageal neoplasms; Esophageal squamous dysplasia; Cross  sectional survey; Serum markers Esophageal squamous cell carcinoma of the world (esophageal squamous cell carcinoma, ESCC) the number of new cases emerging i