Fluoride on the development of mouse molars.docVIP

 PAGE \* MERGEFORMAT 11 Fluoride on the development of mouse molars Of: Hou iron boat, Tao Hong, Zhufeng Yan, Wang handsome [Abstract] Objective To investigate the high fluoride environment on development of mouse molars. Methods animal models of acute fluoride poisoning, with HE staining to observe the high fluoride environment mandibular first molars in bud stage, cap like period, the occurrence of bell shape, differentiation, secretion, mature ameloblasts morphological changes, and while observing the normal tooth development in mice. Results for the control group developed bell stage molars, the experimental group still in the cap stage. bell-like differentiation of the experimental group, secretory ameloblast cells grow shorter, part of the disappearance of cell polarity, cell derangement. Conclusion molar excess fluoride intake can significantly delayed development. overdose fluoride on the division bell , secretory ameloblasts have a strong influence of cell morphology. [Keywords:] tooth development, fluoride poisoning, molar ABSTRACT: Objective To study the tooth germ development of mouse molar in fluorosis. Methods We established an acute fluorosis model and used HE staining after preparing specimens of different stage of mouse first molar developing tooth germ. Results The developing molars of the control fetuses were at the bell stage of odontogenesis, whereas those of the experimental population were at cap stage. The ameloblasts became shorter and lost polarity. The arrangement of ameloblasts fell into disorder at the bell of differeiational stage and secretory stage. Conclusion The developing molars of the experimental fetuses were retarded. High dose fluoride has a strong effect in the ameloblasts at the bell of differetiational stage and secretory stage. KEY WORDS: tooth germ development; fluorosis; molar The formation of dental fluorosis in the enamel development of the secretory phase, or maturity, has been controversial issu