Fluoro-shore combined with anti-CD la Pyridaben monoclonal antibody and amifostine treatment of elderly chronic lymphocytic leukemia.docVIP

 PAGE \* MERGEFORMAT 22 Fluoro-shore combined with anti-CD la Pyridaben monoclonal antibody and amifostine treatment of elderly chronic lymphocytic leukemia Author: Liu Yang, Zhu Hongli, Lu Xue-Chun, Su-Xia Li 【Abstract】 chronic lymphocytic leukemia (CLL) is a malignant lymphoproliferative disease, the elderly prone. CLL treatment of the current main problems: ① treatment of low complete remission rate; ② CLL associated with immune system disorders and treatment of bone marrow suppression, infection, side effects, elderly patients with difficult to tolerate. Section I of this study to successfully treat one cases of 74-year-old B-cell chronic lymphocytic leukemia. Used in the treatment of nucleotide reductase inhibitor that is fludarabine, combined with anti-CD20 monoclonal antibody program, according to the standard therapeutic dose administration, and adjusted according to individual patient administration time, the use of pan-cell protective agent amifostine for adjuvant therapy. The results showed that: a course of treatment to achieve complete remission after treatment, peripheral blood cell counts and classification of back to normal; continue to invest in amifostine adjuvant therapy for 20 days, in patients with anemia be corrected, hemoglobin stabilized at 120 g / L or more chemotherapy drugs side-effects and complications have been effectively controlled. Conclusion: The elderly CLL patients during chemotherapy, the use of fluoride pyridaben pull-bin combined with anti-CD20 monoclonal antibody program, according to standard-dose administration, at the same time to adjust the dose according to patient’s own order and delivery time, reflect the personalized treatment, a satisfactory effect ; Amifostine can effectively reduce or overcome the immune system function associated with CLL disorders, as well as fluoride pyridaben pull-bin, anti-CD20 monoclonal antibody induced bone marrow suppression, infection, fever and other side effects.