Food restriction on aging anti-aging effects in rats.docVIP

 PAGE \* MERGEFORMAT 12 Food restriction on aging anti-aging effects in rats [Abstract] Objective To study food restriction in aged rats the biological effects of aging and to explore its possible mechanism. Methods 11 SD rats were 68 months old, were randomly divided into 3 groups, the experimental group rats were given appetite control 80% and 60%, 6 months after the measurement of serum superoxide dismutase (SOD, malondialdehyde (MDA, interleukin 2 (IL 2, brain monoamine oxidase (MAO hepatocyte apoptosis index. Results The serum SOD activity, IL 2 levels were markedly increased (P lt;0.05), serum MDA levels of brain MAO activity, hepatocyte apoptosis index was significantly lower than the control group (P lt;0.01). Conclusion Self the beginning of diet restriction on aging, with the biological effects of aging. [Keywords:] dietary restriction, aging, apoptosis of liver cells, biological effects Dietary restriction (dietary restriction, DR, that is the body of various nutrients to meet requirements under the premise of appropriate restrictions on food intake, can significantly slow the rate of aging and prolong life in experimental animals. Many experiments continue to confirm that rodents From an early age, the normal daily intake limit of 10% to 30%, not only does not cause malnutrition, may also set longer than the normal feeding 10% to 30% of the average and maximum life span. From the beginning of adult diet restriction can be extended maximum lifespans of mice 10% to 20% (1). For the aging diet restriction on animals, little research has been reported. In this study, diet restriction on aging rats began to explore the biological effects of the body changes in a number of and the possible mechanism for anti-aging research to provide new experimental evidence. 1 Materials and methods 1.1 Grouping The present study, SD rats of clean grade, 10 to 11 months of age, by the Experimental Animal Center of Sun Yat-sen. 68 rats were divided into