Free testosterone index in the diagnosis of polycystic ovary syndrome hyperandrogenism value of infertility patients.docVIP

 PAGE \* MERGEFORMAT 18 Free testosterone index in the diagnosis of polycystic ovary syndrome hyperandrogenism value of infertility patients Of: Lin Xiufeng Du Jing Wu Ran Liao Yuechan at Ye Du Yan Yao Wu Jia Qi Zhang Xubin heroic [Abstract] [Objective] To investigate the free testosterone index in the diagnosis of polycystic ovary syndrome (PCOS) patients with hyperandrogenism value of infertility. [Method] 1113 cases of infertile patients were prospectively studied in the observation group (PCOS group) 533 cases; the control group (normal ovulatory infertile women with non-PCOS) 580. One study group according to body mass index (BMI) sub-obese PCOS group (109 cases) and non-obese PCOS group (424 cases). detection based reproductive endocrinology hormones, sex hormone binding globulin (SHBG), fasting plasma glucose (FPG), fasting insulin (FINS), and calculated free testosterone index (FAI) and insulin resistance index (HOMA-IR). Comparison of the indicators in each group, and to explore free testosterone index in the diagnosis of polycystic ovary syndrome (PCOS) patients with hyperandrogenism value of infertility. [Results] PCOS group based luteinizing hormone (LH) levels, LH / follicle stimulating hormone (FSH) ratio, FAI, FINS , HOMA-IR were higher than the normal group, SHBG levels lower than normal group (P lt;0.05), the difference was statistically significant. The total testosterone level between the two groups was not significant. Logistc regression analysis indicated by HOMA-IR, LH / FSH ratio, FAI, LH are the basis of risk factors for PCOS. including LH / FSH ratio to 1.1 as the threshold, FAI to 3.08 as the threshold, HOMA-IR to 1.95 as the threshold, the ROC area under the curve (AUC-ROC ) were 0.738,0.792,0.772. in the obese PCOS group, HOMA-IR in the diagnosis of PCOS highest sensitivity and negative predictive value (91.74%, 83.63%), and with the LH / FSH ratio of sensitivity and negative predictive value (52.29%, 50.94 %) the difference wa