HPLC determination of nicergoline in the nasal spray of ferulic acid in microemulsions.docVIP

 PAGE \* MERGEFORMAT 9 HPLC determination of nicergoline in the nasal spray of ferulic acid in microemulsions Author: LIU Yi-Fan Yang Jie Guo-wen Chen Ying Song Fenglan [Abstract] Objective To develop a nasal spray emulsion nicergoline of ferulic acid by HPLC method. Methods RP-HPLC column was Waters C18 column (150 mm * 4.6 mm, 5 μ m); with methanol -1% acetic acid (35:65) as mobile phase; detection wavelength 323 nm; flow rate of 1.0 ml / min. The results of ferulic acid in the concentration of 7.6 ~ 76 μ g / ml range a good linear relationship, r = 0.999 5. The average recovery was 98.68%, RSD of 1.33%. Conclusion The method is simple, fast, accurate, reproducible and can be used to pass the brain nasal spray emulsion of ferulic acid in quality control. [Keywords:] Brain Pass nasal spray microemulsion ferulic acid by high performance liquid chromatography Abstract: ObjectiveTo establish the determination method of ferulic acid in Naotong microemulsion. MethodsHPLC was used with Waters C18 column (150 mm * 4.6 mm, 5 ?? m), and the mobile phase consisted of methanol-1% acetic acid (35:65). The detective wavelength was set at 323nm. The flow rate was 1.0 ml / min.ResultsFerulic acid was linear in the range of 7.6 ~ 76 μ g / ml, r = 0.999 5. The average recovery of ferulic acid was 98.68%, and RSD was 1.33%. ConclusionThe method is simple, rapid, accurate and reliable and can be used to control the quality of ferulic acid in Naotong microemulsion. Keywords:: Naotong Microemulsions; HPLC; Ferulic acid Ischemic stroke (AIS) is a serious threat to human health, one of the major diseases, their mortality and morbidity remained high, but it still lacks an ideal treatment, become a worldwide medical problem [1,2] . Prescription nasal drops mainly composed of nicergoline medicine musk, Chuanxiong, 37, leech, borneol, etc., clinical studies have shown that its effectiveness for the treatment of AIS significantly [3]. However, due to the complicated ingredients of