HPLC Determination of the content of ibuprofen tablets Ibuprofen.docVIP

 PAGE \* MERGEFORMAT 5 HPLC Determination of the content of ibuprofen tablets Ibuprofen [Abstract] using HPLC determination of the content of ibuprofen ibuprofen tablets. In the context of 0.2 ~ 3.0μ g showed good linear relationship, correlation coefficient r = 0.9999, average recovery was 99.17%, RSD values of 0.69%, this method is simple, rapid, accurate, and can be used as a method for determination of this product. [Keywords:] HPLC method; ibuprofen; content [Abstract] HPLC method was established for the determination of Ibuprofen in Ibuprofen Tablet. The linear range was within 0.2 ~ 3.0μ g with correlation coefficient of 0.9999. The average recovery rate was 99.17% with RSD 0.69%. The method is simple, rapid and accurate. It can be used as determination method for the product. [Keywords:] HPLC; Ibuprofen; content The main ingredient is ibuprofen ibuprofen, are analgesics. Determination of the content of the current method of preparation for ‘The 2005 edition of Chinese Pharmacopoeia contains two income [1], is the acid-base titration. As the use of vertical dissolving funnel filter, time-consuming and error is greater, so this paper, HPLC Determination of ibuprofen content of this preparation. The method is simple, rapid and accurate determination of this product can be used as methods, are reported as follows. An instrument and reagent 1.1 Instrument Shimadzu LC-10Avp high-performance liquid chromatography (autosampler), SPD-10Avp UV detector, LC-10Atvp high-pressure pump, SiL-HTA system controller. 1.2 test ibuprofen tablets (Shanxi Hengrui Da Pharmaceutical Co., Ltd.); ibuprofen reference substance (100179-200303 Chinese medicines and biological products) for the determination of use; chromatography pure acetonitrile; HPLC pure methanol; dihydrogen phosphate potassium, sodium dodecyl sulfate, phosphoric acid (AR); high water. 2 Experimental Methods and Results 2.1 Chromatographic conditions and system suitability test column: C18 column 5μ m