Huang TF pairs of Aβ dementia caused by the impact of learning and memory in rats.docVIP

 PAGE \* MERGEFORMAT 7 Huang TF pairs of Aβ dementia caused by the impact of learning and memory in rats Author: Ye Yan-Zhen Guan Lihua Wang Ruiting left Shenxing bin [Abstract] Objective To observe the Huang TF on rats with bilateral hippocampal injection of Aβ 25-35 induced learning and memory and neuronal morphology. Methods 30 male Wistar rats were randomly divided into blank control group, model group, the total flavonoid group. Blank control group fed distilled water and 1 / d, a total of 7 d, on the 8th day, hippocampus injected with normal saline, to continue gavage; model group on the 8th day hippocampal injection of Aβ 25-35 5 μ l containing 10 μ g, others with the control group; treatment group 50 mg / kg per day of total flavonoids fed a times, a total of 7 d, on the 8th day hippocampal injection of Aβ 25-35, continue to gavage, each group in the first 15 days using Morris water maze test of learning and memory ability of rats and 1 / d, measured 5 d, death, Nissl staining of hippocampal pyramidal cells changes. Results In the model rats escape latency was significantly longer than the control group, hippocampal areas CA1 pyramidal cells with Tuoshi, incomplete, cell vacuolar degeneration occurred in treatment group compared with the model group rats escape latency shortened and less cell damage. Conclusion Huang TF hippocampal injection of Aβ 25-35 induced learning and memory damage and morphological changes of hippocampal neurons have a protective effect. [Keywords:] Alzheimer’s disease amyloid protein Huang TF Abstract: ObjectiveTo investigate the protection of SSTF on memory deficit, neuronal degeneration induced by bilateral injection Aβ 25-35 in rat hippocampus.Methods30 male Wistar rats were randomly divided into three groups. The distilled water was given (ig, 1 / d) to the comparision group and the model group, SSF (ig 50mg/kg/d 1 / d) was given to SSF group. On the eighth day saline or Aβ was injected to bilateral hippocampus of the c