Huazhuo detoxification and stomach of Chronic atrophic gastritis and gastric cancer patients with the treatment of precancerous lesions.docVIP

 PAGE \* MERGEFORMAT 14 Huazhuo detoxification and stomach of Chronic atrophic gastritis and gastric cancer patients with the treatment of precancerous lesions Study: High Shao Fang Dian Li, Chang Wan Zhang Jinli you Cui history from the innocent Abstract Objective To investigate the gastric side Huazhuo detoxification and chronic atrophic gastritis (CAG) in the treatment of precancerous lesions and its mechanism. Methods 110 cases of precancerous lesions of CAG patients were randomly divided into treatment group (55 cases) and stomach side Huazhuo Jiedu given orally, the control group (55 cases) given Weifuchun tablet, a course of 6 months. Were observed in patients with clinical endoscopy, pathology and treatment efficacy before and after the expression of Cyclin D1 and PTEN integral value changes. Results of Endoscopic Mucosal Shiraai the treatment group and the improvement of bile reflux than the control group, compared the pathological effect of changes in the treatment group than the control group showed a high cure rate; Immunohistochemistry showed that the stomach can only Huazhuo detoxification and significantly inhibited Cyclin D1 expression, increased PTEN expression (P lt;0.05). Conclusion Huazhuo detoxification and gastric side of the endoscopic signs of precancerous lesions of CAG, pathological changes to improve the role, and its mechanism of inhibiting the activation of oncogenes and tumor suppressor gene inactivation, and promote apoptosis of precancerous cells. Keywords: gastritis; Atrophic / TCM therapy; Precancerous Conditions / TCM therapy; Cyclin D1; PTEN Chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) and dysplasia (ATP) is a precancerous lesion of gastric cancer 1. Precancerous lesions (PLGC) is the transformation of gastric cancer from normal to an important stage in the process. PLGC block and reverse the development is to reduce the incidence of gastric cancer is one of effective measures, but there