Human and rat coronary artery comparative study of age-related changes.docVIP

 PAGE \* MERGEFORMAT 12 Human and rat coronary artery comparative study of age-related changes [Abstract] Objective To investigate the human and rat coronary artery wall structure and diameter changes with aging, as well as species differences. Methods for newborns, adults, elderly people three groups of coronary artery wall structure and aging changes in the level of doing light microscopy quantitative observation. Pairs of young, aged rats had coronary heart level of electron microscopy observation. The results of rat coronary artery and the coronary artery wall structural changes in people’s minds there are obviously different. Human coronary artery wall very significant age-related changes, neonatal coronary artery intima only by a thick layer of endothelium and internal elastic membrane composition, to adulthood and old age, the endothelial lining appears in the lower and varying degrees of thickening, Some of the development of atherosclerosis, so that the lumen becomes smaller. In the rat coronary artery, whether young or old, its only by the endothelial lining composition, no underlying internal elastic membrane and endothelium, thus from infancy to old age has not intimal thickening and luminal narrowing of the phenomenon. Conclusion The coronary artery wall by a significant age-related changes in rat coronary artery had no significant age-related changes, differences between the two species more significant. Anatomical differences in this comparison, suggesting that studies using animal experiments to explain some mechanisms of the human need to be cautious. [Keywords:] Coronary artery; aging changes; morphology; light / electron microscopy Comparative research on aging changes of coronary arteries in humanbeings and rat [Abstract] Objective To investigate the aging changes and species differences on the structure and caliber of the coronary arteries of human and rat. Methods Anterior interventricular branches of the left coronary arteries,