Myelopathy of Research.doc

 PAGE \* MERGEFORMAT 13 Myelopathy of Research [Keywords:] spinal cord lesions, myelopathy, hepatic encephalopathy Myelopathy (hepatic myelopathy, HM liver disease is a rare disease caused by spinal cord lesions, first reported in 1949 abroad. The disease manifested as chronic progressive increase of the symmetry of spastic paraplegia and spinal cord pyramidal tract signs, not accompanied by sensory and sphincter dysfunction, pathology showed demyelination, spinal cord lateral to the center, symmetrical, affecting the following spinal cord to thoracic and the most obvious [12]. Statistics based on case reports and abroad, gathered at the age of 24 to 63 years old, mostly male, liver disease accounted for 2% to 4% [3]. mainly seen in hepatic encephalopathy with multiple episodes or administration of the door - shunts in patients with cirrhosis of the liver, occasionally in the acute and chronic hepatitis, alcoholic fatty liver, congenital hepatic fibrosis and liver degeneration and so on. As people’s living standards improve, there is a growing trend of this disease, to enable clinicians to better understanding, diagnosis and treatment of this disease, the present disease Research summarized below. Etiology and pathogenesis 1 Etiology and pathogenesis of this disease is unclear, most scholars believe that the decline is due to the liver detoxification function, toxic substances into the blood circulation, direct damage to the spinal cord, causing the disease. HM because the vast majority of patients with advanced cirrhosis, and all surgical shunt or evidence of spontaneous shunt, so the HM portosystemic shunt may be the cause. However, a small number of acute and chronic hepatitis, fatty liver, but nowhere were merged HM shunt, so portosystemic shunts alone can not explain the occurrence of all HM. Currently on the liver Pathogenesis of spinal cord there are several theories. 1.1 Chronic poisoning theory Because spontaneous, postoperative, and