Neonatal cytomegalovirus infection with subclinical brain damage caused by early diagnosis and intervention.doc

 PAGE \* MERGEFORMAT 7 Neonatal cytomegalovirus infection with subclinical brain damage caused by early diagnosis and intervention Cytomegalovirus (CMV infection early symptoms are not typical, easily misdiagnosed or missed diagnosis. Nearly 10% of infected newborns showed subclinical infection, a short time without specific clinical manifestations of the nervous system, but then can cause brain dysfunction. Nerve specific enolase (neuronspecific enolase, NSE) is the sensitivity of neuronal injury markers with high specificity. We detection of cytomegalovirus infection in neonatal serum NSE concentration and ability to neonatal behavioral neurological assessment ( neonatal behavioral neurological assessment, NBNA), to determine the serum NSE in the early brain damage in newborn value of sub-clinical and therapeutic intervention of Astragalus. 1 Data and methods 1.1 Object experimental groups: both by the qualitative detection of CMV-IgM positive, eliminate the virus other than CMV infections, diagnostic criteria for diagnosis of cytomegalovirus infection by the program [1], except for clinical perinatal asphyxia, neonatal hypoxic-ischemic brain disease, bilirubin encephalopathy, central nervous system infections, no clinical manifestations of the nervous system. Determination 2008 7-2010.7 admitted to our hospital meet the above criteria, 40 neonates. including 22 males and 18 females. randomly divided Astragalus intervention group and for the conventional treatment group. Control group: for the same period in full-term healthy newborns in 22 cases, gestational age, age, weight and gender and no significant difference between the experimental group (Pgt; 0.05), comparable. 1.2 Methods 1.2.1 Determination of serum NSE: 40 cases of children admitted to hospital after the experimental group to take the morning fasting blood 3ml quiet submission. The control group at the same time venous blood 3ml physical inspection. By enzyme-lin