Photodynamic therapy on tumor cell signaling pathways Progress of Studies.doc

 PAGE \* MERGEFORMAT 23 Photodynamic therapy on tumor cell signaling pathways Progress of Studies [Abstract] This paper review of photodynamic therapy on tumor cell signaling pathways of research results, further analysis of the role of photodynamic therapy may be anti-tumor mechanism of action, the role of light power in depth a variety of possible mechanisms were discussed. [Keywords:] photodynamic therapy, cancer, signal transduction Photodynamic therapy (photodynamic therapy, PDT, also known as the optical radiation therapy (photoradiation therapy or photochemotherapy (photochemotherapy. this method is the use of photosensitizer molecules, after receiving specific wavelengths of light energy by photochemical reactions and energy transfer in the light molecule can be converted into energy under aerobic conditions, resulting in a variety of reactive oxygen species (ractive oxygen species, ROS, including singlet oxygen (1O2, oxygen free radicals, hydroxyl radicals, hydrogen peroxide, and thus protein destroying the nucleic acids and the role of lipid molecules, the cell structure and function of severely affected, leading to cell apoptosis or death, and play a therapeutic role. The effect of two types: one is the photosensitizer by electronic or protons ( e or H + transfer redox reactions caused by free radicals, known as photodynamic reaction type Ⅰ, the other is the energy transfer to the photosensitizer to the oxygen molecule making it around the singlet oxygen, known as photodynamic reaction type Ⅱ. PDT can be relatively specific to its selective killing of tumor cells, tissue injury to health, few complications and side effects etc, and make it a very promising cancer treatment. PDT effect and the role of The use of photosensitizer type, exposure conditions, tissue oxygen metabolic state, cell type, of which photosensitizer in the cell binding site for the initial decision of the PDT and the most important site of injury [1]. Cell signal trans