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Phyllanthus an effective part of the total extract of the general pharmacological effects of.docVIP

Phyllanthus an effective part of the total extract of the general pharmacological effects of.doc

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    Phyllanthus an effective part of the total extract of the general pharmacological effects of

     PAGE \* MERGEFORMAT 18 Phyllanthus an effective part of the total extract of the general pharmacological effects of Author: Wen Zhijian, Zhou Yonglu, Cao Yu, PENG Ling 【Abstract】 Objective To observe the effective parts of Phyllanthus total extract of a second intragastric administration of the central nervous system, cardiovascular system, respiratory system effects. Methods Phyllanthus extract an effective part of the total 500,250,125 mg * kg-1 time intragastric administration, goods of mice to observe the sodium pentobarbital sleep time, sleep, sodium pentobarbital, and a subthreshold dose second gavage 600,150 mg * kg-1 in mice independent activities; Phyllanthus effective part of the total extract of 47,470 mg * kg-1 duodenal administration, observation of mongrel blood pressure, respiration, heart rate, ECG effects. The results of sodium pentobarbital sleeping time in mice, mice under pentobarbital sodium sleep threshold dose, no effect on locomotor activity in mice. The dog blood pressure, respiration, heart rate, electrocardiogram (P  R interval, QT interval, T wave) had no effect. Conclusions from Phyllanthus extract an effective part of the total dose range used, does not appear on the central nervous system, cardiovascular system, respiratory system have significant effect. Keywords: Phyllanthus urinaria effective parts; pharmacological effects Abstract: ObjectiveTo observe the effects of total extracts of Yexiazhu on nervous system, cardiovascular system, and respiratory system in mice and dogs.MethodsThe times of freedom movement in mice, the effect on the hypnotic dosage and subthreshold hypnotic dosage of Pentobarbital Sodium in mice, the blood pressure, heart rates in dogs were observed.ResultsThe blood pressure, heart beat rate, heart rhythm, respiratory rate, depth of respiration, freedom movement, hypnotic dosage and subthreshold hypnotic dosage of pentobarbital Sodium in animals had no obvious difference a

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