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Phyllanthus an effective part of the total extract of induced mutation in Experimental Research.docVIP

Phyllanthus an effective part of the total extract of induced mutation in Experimental Research.doc

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    Phyllanthus an effective part of the total extract of induced mutation in Experimental Research

     PAGE \* MERGEFORMAT 10 Phyllanthus an effective part of the total extract of induced mutation in Experimental Research 【Abstract】 Objective To evaluate the effective part of the total Phyllanthus extract mutagenicity. Methods The micronucleus test, Ames test and in vitro chromosomal aberration test right from Phyllanthus extract an effective part of the overall detection of the mutation. The results of bone marrow cells in mice micronucleus test did not find bone marrow cells micronucleus rate increased, Ames test against TA97, TA98, TA100, TA102 4 strains with and without added S9 were not found to change back to increase the number of colonies, in vitro chromosome aberration test Canadian and without S9 were not found in chromosomal aberration rate of over 5%. 3 The experimental results were negative. Conclusion In the experimental conditions, were not detected from Phyllanthus extract an effective part of the total mutagenicity. Keywords: Phyllanthus an effective part of the total extract of mutagenesis in vivo micronucleus test in mice bone marrow cells in vitro micronucleus test Ames test chromosome aberration test Study on Mutagenicity of Total Extracts of Yexiazhu (TEY) Abstract: ObjectiveTo evaluate the mutagenicity of total extracts of Yexiazhu (TEY). MethodsThe micronucleus test in mice, Ames test and chromosome aberration test were carried out.ResultsThe micronucleus rates in all doses were not significantly different from the control group. No increase in the number of revertant colonies was found in the Ames test with and without S9 activation system. Negative results were seen from chromosome aberration test in CHL cell. ConclusionNo mutagenicity effects of TEY were detected in this study. Keywords:: Total extracts of Yexiazhu; Mutagenicity; Micronucleus test in mice; Ames test; Chromosome aberration test Phyllanthus extract an effective part of the total general pharmacology studies, long-term toxicity

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