Rotavirus enteritis in cellular immune function of.docVIP

 PAGE \* MERGEFORMAT 9 Rotavirus enteritis in cellular immune function of Of: Zhang Xuejun, Liu Zuoyi, Yin Xiangui [Abstract] Objective To investigate risk of infant rotavirus (Rotavirus, RV) enteritis when the body’s cellular immune status, for prevention and treatment of infant enteritis RV to open up new ideas. Determined 30 cases of RV enteritis in infants blood T cell subsets, with the same period 11 normal infants as controls. Results RV enteritis in children with blood CD3 +, CD4 + and CD4 + / CD8 + ratio was significantly lower than the control group (P values #8203;#8203;were lt;0.01, “0.05 and” 0.05), while CD8 + cells and the control group had no significant differences, CD3 +, CD4 + cells in RV enteritis severe with mild decreased, the difference was significant (P lt;0.05 and “0.01), while CD8 + and CD4 + / CD8 + ratio in a variety of disease was no significant difference. Conclusion infant RV enteritis, the cellular immune function is suppressed, so that the systemic and local B cell proliferation and antibody secretion decreased, to reduce RV infection protection and function. Therefore, the determination of CD4 +, CD4 + / CD8 + ratio may enteritis prognosis, efficacy and outcomes have diagnostic value. [Keywords:] rotavirus enteritis; infants and young children; T cell subsets [Abstract] Objective To explore the cell immunity of infants with rotavirus (RV) enteritis and lay the groundwork of new therapy for treating infants with RV enteritis.Methods The blood specimens collected from 30 infants with RV enteritis and control were measured for the level of subset of T lymphocyte.Results CD3 +, CD4 + and the ratio of CD4 + / CD8 + were reduced obviously in RV enteritis compared with the control (P lt;0.01, lt;0.05 and lt;0.05 respectively), and no difference level of CD8 + were found between RV enteritis group and control, CD3 + and CD4 + were reduced obviously in serious enteritis than light enteritis (P lt;0.05 and lt;0.01). CD8 + and