Salvia endotoxin induced acute lung injury on rat lung water channel protein -1 in the regulation effect.docVIP

 PAGE \* MERGEFORMAT 15 Salvia endotoxin induced acute lung injury on rat lung water channel protein -1 in the regulation effect Of: Li Min, Li Feng, Hu Bo, Wang Chaofeng [Abstract] Objective Salvia lipopolysaccharide (LPS) induced acute lung injury (ALI) rat lung water channel protein -1 (AQP-1) regulation. Methods 48 SD rats were randomly divided into normal, SM Pre-injection protection group, Danshen injection 7 d treatment group, ALI 7 d model group, Danshen injection 8 h treatment group, ALI 8 h model group, n = 8. respectively, 8 h, 7 d and electron microscopy and HE staining of the pathological changes of lung tissue, lung wet / dry weight ratio (W / D) and changes in lung water permeability, immunohistochemistry and lung tissue were detected after Western blotting the expression of AQP-1 change; measured blood oxygen PaO2, blood rheology, endothelin -1 (ET-1) concentrations. Results The groups were there symptoms of lung injury. Danshen injection 7 d treatment group, the pathological changes of pulmonary edema and ALI 7 d model group was significantly reduced, significantly improved blood rheology, but the two groups of AQP-1 expression was no significant difference between the normal group (P lt;0.05). Danshen injection 8 h treatment and protection of Danshen injection group and the pre-ALI 8 h model group, the pathological changes of pulmonary edema was reduced significantly improved blood rheology (P lt;0.05), which pre-protection of Danshen injection group AQP-1 expression increased significantly (P lt;0.01). Conclusion SM may regulate AQP-1 expression to improve water metabolism, improve blood rheology ALI in rats, thus reducing the state of pulmonary edema, suggesting that the pharmacological effects of Salvia new basis. Keywords:] Salvia, acute lung injury, lipopolysaccharide, water channel protein, hemorheology Abstract: Objective To investigate the effect of SM on aquaporin-1 (AQP-1) expression in rats with acute lung injury (ALI) i