Sedative and hypnotic effect of Prunella preliminary study.docVIP

 PAGE \* MERGEFORMAT 13 Sedative and hypnotic effect of Prunella preliminary study Author: Zhao Jiang Li Xiang-Yang Wu Yang Liu Qing Li Yongjin Wang Wen-Wen Zou Min [Abstract] Objective To compare the different extracts of Prunella sedative and hypnotic effects. Methods sedation, hypnosis experimental method to observe the Prunella vulgaris extracts on mice of different activities, the impact of autonomy as well as sodium pentobarbital sleep in mice synergy. Results Prunella vulgaris alcohol extract and the chloroform extract parts and parts of ethyl acetate extracts are able to significantly reduce the number of independent activity in mice to increase the threshold dose of pentobarbital sodium induced sleep is only a few, to extend the threshold on the dose of E. Pakistan sodium than the proper sleep time in mice. Conclusion Prunella vulgaris alcohol extract and its chloroform extraction site and parts of ethyl acetate extract all have significant sedative and hypnotic effects. [Keywords:] Prunella vulgaris; sedation; hypnosis Abstract: Objective To study the sedative and hypnotic effects of the different extracts of Spica prunellae. MethodsSedative and hypnotic experiments were made to observe the effects of different extracts of Spica prunellae on spontaneous motion and hyponosis in mice. ResultsThe ethanol extract of Spica prunellae together with its chloroform extract and ethylacetate extract could markedly inhibit spontaneous motion, enhance the sleeping number of pentobarbital sodium (subthreshold dosage) and prolong the sleeping time of sodium pentobarbital (superthreshold dosage). ConclusionThe ethanol extract of Spica prunellae together with its chloroform extract and ethylacetate extract has obvious sedative and hypnotic effects. Keywords:: Spica prunellae; Sedative; Hypnosis Insomnia refers to the origin of sleep and sleep maintenance took place obstacles is quality or quantity of sleep not meet the normal requirements of a subjective exper