SDF-1 receptor CXCR4 in human epithelial ovarian tumors and their significance.docVIP

 PAGE \* MERGEFORMAT 16 SDF-1 receptor CXCR4 in human epithelial ovarian tumors and their significance Of: the main change Xia, Zhang Min Ge, Duan Zhao, Ying Liu [Abstract] Objective To investigate the chemokine SDF-1 and its receptor in ovarian epithelial tumors CXCR4 tissues and its clinical significance. Immunohistochemical SP method was detected 10 cases of normal ovarian epithelial tissue, 21 cases of benign ovarian tumors, 19 cases of borderline ovarian tumors, 30 cases of ovarian cancer and 11 cases of primary tumors corresponding pelvic metastasis tissue SDF-1 and CXCR4 protein. The results of normal ovarian epithelial tissue expression of SDF-1 and CXCR4 negative, benign ovarian tumors of low expression SDF-1 (9.52%), CXCR4 expression was negative, with normal ovaries and benign ovarian tumors compared to borderline ovarian tumors, ovarian cancer and metastatic primary tumors expressed higher levels SDF-1 and CXCR4 (63.16%, 93.33%, 90.91%, 47.37%, 63.33%, 63.64%). borderline ovarian tumors in the SDF-1 and CXCR4 expression was not significantly correlated (P = 0.460), and ovarian cancer, primary tumors, SDF-1 and CXCR4 expression was positively correlated (P lt;0.05), SDF-1 expression in ovarian cancer patients with clinical stages, histological grade was no significant correlation (Pgt; 0.05), but with patients without ascites had a correlation (P lt;0.05) , CXCR4 expression in ovarian cancer patients with clinical stage, histologic grade, and patients without ascites had no significant correlation (Pgt; 0.05). Conclusion SDF-1/CXCR4 expression and cell malignant transformation, which may participate in ovarian the incidence of cancer development, invasion and metastasis. [Keywords:] ovarian cancer, immunohistochemistry, stromal cell derived factor -1 (SDF-1), CXC chemokines receptor 4 (CXCR4) ABSTRACT: Objective To investigate the expression and significance of chemokine SDF-1 and its receptor CXCR4 in epithelial ovarian tumour. Methods T