Transforming growth factor-β on atherosclerosis in the vascular smooth muscle cells and its impact.docVIP

 PAGE \* MERGEFORMAT 19 Transforming growth factor-β on atherosclerosis in the vascular smooth muscle cells and its impact [Keywords:] transforming growth factor-β in vascular smooth muscle cells in atherosclerosis Vascular smooth muscle cells (VSMCs) of the activation, proliferation and migration is the development of atherosclerotic lesions of the necessary conditions for [1]. In physiological conditions, VSMCs synthesize and secrete collagen and other extracellular matrix of normal maintenance of normal vascular structure and function. However, the early formation of plaque, VSMCs migrate from the blood vessels in the membrane to the intima, thus proliferation and phenotypic change occurs, synthesis and secretion of extracellular matrix, the release of a variety of growth factors, cytokines, lipid uptake into muscle can -derived foam cells. After several decades of development, VSMCs and other cells with the ultimate formation of large plaques obstruct blood flow. Transforming growth factor-β (Transforming Growth Factor, TGF-β ) is a kind of multifunctional peptide growth factor involved in regulating embryonic development, cell growth and differentiation, extracellular matrix synthesis, inflammation, wound healing and immune and many other biological processes [2]. In recent years, studies have shown that, TGF-β through its anti-inflammatory, immune regulation and the promotion of extracellular matrix (EMC) the role, limiting atherosclerosis (AS) development. In particular, TGF-β on VSMCs proliferation, migration, and phenotypic transformation of an effect, thus affecting the atherosclerotic plaque formation, development and plaque stability, reducing the occurrence of acute coronary events played a significant role. A transforming growth factor-β and its receptor in the biological characteristics of TGF-β has been found that there are five kinds of isomers, namely, TGF-β 1 ~ TGF-β 5, which only exist in the human body there are TGF-β 1, TGF-