rhBMP-2在脊柱融合术中安全性的研究进展.pdfVIP

解及建议。 方法 应用 CNKI、万方全文数据库、Pubmed、Springerlink 数据库检索系统以“重 组人体骨形态发生蛋白(rhBMP-2);腰椎融合;并发症;骨溶解;逆行性射精”为关键 词分别或联合检索相关文献，按其因素不同分别进行归类总结。 结果：对相关文献进行分析总结后，得出 rhBMP-2 在腰椎融合术中可与新发神经 根损伤、异位骨化、骨溶解、逆行性射精以及潜在致癌效应有关。在颈椎中可能 导致颈前水肿及吞咽困难、骨溶解及移植物沉降、迁移、血肿形成。 结论：rhBMP-2 在脊柱手术中应当暂且严格限制其适应症，不推荐作为常规应用于脊柱融 合术中。仅建议用于那些植骨不融合的风险大过使用rhBMP-2 带来的风险的患者，比如：接 受翻修手术的假关节形成患者、老年骨质疏松症患者、存在长期吸烟等增加骨质愈合难度的 患者以及自体骨的质量较差等患者。总之，在应用rhBMP-2 之前，要慎重思考、权衡利弊。 【关键词】重组人体骨形态发生蛋白 (rhBMP-2);腰椎融合 ;并发症;骨溶解;逆行 性射精 Research Progress on the safety of rhBMP-2 in spinal fusion surgery Abstract Background:. Since rhBMP-2 was discovered, has been the research focus of bone graft materials, but because of its failure to widely used in clinical, concerning its safety can only stay in the stage of theory discussion. In recent years along with rhBMP-2 are more and more widely used in spinal fusion, adverse events related to BMP reported in clinical is also becoming increasingly common. The common complications included: can cause inflammation and nerve tissuerejection, because of its excessive spinal nerve root compression bone effect and cause, alsoincluding urinary system events, male patients after ALIF osteolysis, and potentialcarcinogenic effects. Its safety problems, many scholars questioned. This article rhBMP-2 in spinal operation in the latest research progress of safety review. Objective：The purpose of this study is through the literature review to summarize the 5 progress ofresearch on the security of rhBMP-2 in spinal fusion, to raise awareness of the product related complications, and safety of the clinical application of the understanding and suggestions Methods: The papers were searched from CNKI, Wan Fang data base, Pubmed and Springerlink with