Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture英文文献资料.docVIP

下载本文档

1
0
约2.79万字
约 8页
2017-05-10 发布于上海
举报
版权申诉

Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture英文文献资料.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture英文文献资料

HindawiPublishingCorporation BioinorganicChemistryandApplications Volume2006,ArticleID71938,Pages1–7 DOI10.1155/BCA/2006/71938 AntihumanImmunode?ciencyVirusType1(HIV-1) ActivityofRareEarthMetalComplexesof 4-HydroxycoumarinsinCellCulture IliaManolov,1SevdaRaleva,2PetyaGenova,2AlexeySavov,3LilianaFroloshka,2 DanielaDundarova,2andRadkaArgirova2 1 2 3 DepartmentofOrganicChemistry,FacultyofPharmacy,MedicalUniversity,2DunavStreet,1000So?a,Bulgaria DepartmentofVirology,NationalCenterofInfectiousandParasiticDiseases,44AStoletovStreet,1233So?a,Bulgaria LaboratoryofMolecularPathology,MedicalUniversity,2ZdraveStreet,1606So?a,Bulgaria Received23December2004;Revised9March2005;Accepted17June2005 The cerium Ce(III), lanthanum La(III), and neodymium Nd(III) complexes with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1- benzopyran-2-one(warfarin)(W)and3,3 timeforcytotoxicity(onMT-2cells)andasanti-HIVagentsunderacuteandchronicinfection.Thecomplexeswerecharacterized bydi?erentphysicochemicalmethods:massspectrometry, HNMR, CNMR,andIRspectroscopy.Thespectraofthecomplexes -benzylidenebis[4-hydroxycoumarin](1)weresynthesizedandstudiedforthe?rst 1 13 wereinterpretedonthebasisofcomparisonwiththespectrumofthefreeligands.Anti-HIVe?ectofthecomplexes/ligandswas measuredinMT-2cellsbymicrotiterinfectionassay.Detectionofendogenousreversetranscriptase(RT)activityandRTpro- cessivitybyPCRindicativeforproviralDNAsynthesisdemonstratedthatanti-HIVactivityhasnotbeenlinkedtoearlystagesof viralreplication.Noe?ectonlatestepsofviralreplicationhasbeenfoundusingcellschronicallyproducingHIV-1LAIvirus.La(W) demonstratedanti-HIVactivity(IC50=21.4μM)closetomaximalnontoxicconcentration.Nd(W),Ce(1),andNd(1 )demon- stratedlimitedanti-HIVpotency,sononeofthecomplexesseemsappropriatetobeusedinclinic.FurthertargetingofHIV-1 inhibitionbyLa(W)isunderprogress. Copyright?2006IliaManolovetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductionina