Applications of exponential decay and geometric series in effective medicine dosage英文文献资料.docVIP

Advances in Bioscience and Biotechnology, 2010, 1, 51-54 ABB doi:10.4236/abb.2010.11008 Published Online April 2010 (http://www.SciRP.org/journal/abb/). Applications of exponential decay and geometric series in effective medicine dosage Chinnaraji Annamalai Indian Institute of Technology Kharagpur, Kharagpur, India. Email: anna@iitkgp.ac.in Received 10 March 2010; revised 18 March 2010; accepted 20 March 2010. growth, Q ?t ? , if the quantity Q increases at a rate ABSTRACT proportional to its value over time t . Symbolically, this can be expressed as follows: The problem facing by physicians is the fact that for most drugs there is a minimum concentration below which the drug is ineffective, and a maximum con- centration above which the drug is dangerous. Thus, this paper discusses the effective medicine dosage and its concentration in bloodstream of a patient. For analysis of dose concentration and mathematical mo- delling of minimum and maximum concentration of a drug administered intravenously, the EDM (Expo- nential Decay Model) and GSF (Geometric Series and its Formula) are the powerful mathematical tools. In the present research study, these two mathematical tools were used to predict the dose concentration of a drug in bloodstream of a patient. dQ (t) ? Q (t ) dt dQ?t? ? kQ?t?, which is a differential equa- That is, dt tion. dQ (t) is the rate of change of quantity Q where dt over timet , Q(t) is the value of the quantity Q at time t , and k is a positive number called the growth constant. Now, we can find solution for the differential equation Keywords: Bloodstream; Dose Concentration; Expo- nential Decay; Geometric Series; Medicine dQ?t? ? kQ?t? dt By rearranging this equation, we get dQ ?t? ? kdt 1. INTRODUCTION One of the physician’s responsibilities is to give medi- cine dosage for a patient in an effective manner. In this research study, the effectiv