Bone Health in a Nonjaundiced Population of Children with Biliary Atresia英文文献资料.docVIP

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Bone Health in a Nonjaundiced Population of Children with Biliary Atresia英文文献资料.doc

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Bone Health in a Nonjaundiced Population of Children with Biliary Atresia英文文献资料

HindawiPublishingCorporation GastroenterologyResearchandPractice Volume2009,ArticleID387029,9pages doi:10.1155/2009/387029 ResearchArticle BoneHealthinaNonjaundicedPopulationof ChildrenwithBiliaryAtresia RachelA.Kramer, 1 BabetteS.Zemel, 1 1 JessicaL.Arvay-Nezu, andBarbaraA.Haber 1 1 VirginiaA.Stallings, MaryB.Leonard, 2 1 2 TheDivisionofGastroenterology,HepatologyNutrition,Children’sHospitalofPhiladelphia,PA19104,USA TheDivisionofNephrology,Children’sHospitalofPhiladelphia,PA19104,USA CorrespondenceshouldbeaddressedtoBarbaraA.Haber,haber@ Received7November2008;Revised31March2009;Accepted30April2009 RecommendedbyFabioMarra Objectives. To assess bone health in a cohort of nonjaundiced children with biliary atresia (BA) and the e?ect of growth anddevelopmentonboneoutcomes.Methods.ChildrenagesonetoeighteenyearsreceivingcarefromChildren’sHospitalof Philadelphiawererecruited.Eachchildwasseenonceandassessedforgrowth,pubertaldevelopment,concurrentmedications, bilirubin,ALT,albumin,vitaminDstatus,bonemineraldensity(BMD),andbonemineralcontent(BMC)ofthelumbarspine andwholebody.Results.BMDdeclinedsigni?cantlywithage,anduponfurtheranalysiswithawell-phenotypedcontrolcohort, itwasfoundthatBMCwassigni?cantlydecreasedforbothlumbarspineandwholebody,evenafteradjustmentforconfounding variables.Anageinteractionwasidenti?ed,witholdersubjectshavingasigni?cantlygreaterimpairmentinBMC.Conclusions. ThesepreliminaryresultsdemonstratethatchildrenwithBA,includingthosewithoutjaundice,arelikelytohavecompromised bonehealthevenwhenaccountingforheightandpuberty,whicharecommonconfoundingfactorsinchronicdisease.Further investigationisneededtoidentifythedeterminantsofpoorbonemineralstatusandtodevelopstrategiestopreventosteoporosis laterinlife. Copyright?2009RachelA.Krameretal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. 1.Introduction calcium [3