Can Serum-Specific IgETotal IgE Ratio Predict Clinical Response to Allergen-Specific Immunotherapy in Children Monosensitized to House Dust Mite英文文献资料.docVIP

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Can Serum-Specific IgETotal IgE Ratio Predict Clinical Response to Allergen-Specific Immunotherapy in Children Monosensitized to House Dust Mite英文文献资料.doc

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Can Serum-Specific IgETotal IgE Ratio Predict Clinical Response to Allergen-Specific Immunotherapy in Children Monosensitized to House Dust Mite英文文献资料

HindawiPublishingCorporation JournalofAllergy Volume2012,ArticleID694094,5pages doi:10.1155/2012/694094 ClinicalStudy CanSerum-Speci?cIgE/TotalIgERatio PredictClinicalResponsetoAllergen-Speci?cImmunotherapyin ChildrenMonosensitizedtoHouseDustMite? GulbinBingolKarakoc,MustafaYilmaz,DeryaUfukAlt?ntas?,andSevalG¨unes?erKendirli DivisionofPediatricAllergyandImmunology,FacultyofMedicine,UniversityofCukurova,Balcali,01330Adana,Turkey CorrespondenceshouldbeaddressedtoGulbinBingolKarakoc,gulbinb@.tr Received18November2011;Revised24January2012;Accepted24January2012 AcademicEditor:NazanCobanoglu Copyright?2012GulbinBingolKarakocetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Background. Allergen-speci?c immunotherapy (SIT) is one of the important regimens for the treatment of allergic diseases. Predictive tests for the clinical response to SIT are limited. In this study we aimed to evaluate whether speci?c IgE/total IgE levelscanpredictclinicalimprovementinmonosensitizedpatientstohousedustmitetreatedwithimmunotherapy.Patientsand Methods.Weanalyzed32patientswhohadundergone2yearsofSIT.Serumt-IgEands-IgElevels,andserums-IgE/t-IgEratios werecalculatedandtestedforcorrelationwithclinicalresponsetoSIT.Asthmasymptomscore(ASS),rhinitissymptomscore (RSS),pulmonaryfunctionsandvisualanaloguescales(VAS)wereevaluatedatthebeginningandafter2years.Results.Therewere 17boysand15girlswiththemeanageof10.78±3.03years.Themeanserumhousedustmites-IgElevelwas128.62±142.61kU/L, t-IgE608.90± 529.98IU/mL,ands-IgE/t-IgEratio33.83± 53.18.Beforeimmunotherapy,ASSwas6.23± 1.63,RSS;8.20± 1.88, VAS;7.38± 2.01,FEV1(%);89.14± 8.48,PEF(%);88.93± 13.57,andafter2years,thesevaluesweredeterminedas1.90± 1.10, 3.05±1.39,1.35±1.24,97.6±11.26,and97.0±11.55,respectively.s-IgE/t-IgEratiowascorrelatedwithchangeinRSS(r=?0.392, P =0.08)andVAS(r =?0.367,P =0.05).Conclus