Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation英文文献资料.docVIP

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Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation英文文献资料.doc

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Cardiac Autonomic Imbalance in Newly Diagnosed and Established Diabetes Is Associated with Markers of Adipose Tissue Inflammation英文文献资料

HindawiPublishingCorporation ExperimentalDiabetesResearch Volume2012,ArticleID878760,8pages doi:10.1155/2012/878760 ResearchArticle CardiacAutonomicImbalanceinNewlyDiagnosed andEstablishedDiabetesIsAssociatedwithMarkersof AdiposeTissueIn?ammation DavidC.Lieb, HenriK.Parson, GreggMamikunian, andAaronI.Vinik 1 1 2 1 1 DivisionofEndocrinologyandMetabolism,DepartmentofMedicine,EasternVirginiaMedicalSchool, StrelitzDiabetesCenterforEndocrineandMetabolicDisorders,855WestBrambletonAvenue,Norfolk,VA23510,USA InterScienceInstitute,944WestHydeParkBoulevard,Inglewood,CA90302,USA 2 CorrespondenceshouldbeaddressedtoAaronI.Vinik,vinikai@ Received19July2011;Accepted7September2011 AcademicEditor:NicolaMontano Copyright?2012DavidC.Liebetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Introduction.Diabeticsdiefromcardiovasculardiseaseatamuchgreaterratethannondiabetics.Cardiacautonomicimbalance predicts increased cardiovascular risk and mortality. We studied the relationship between cardiac autonomic imbalance and adiposetissue-derivedin?ammationinnewlydiagnosedandestablishedtype2diabetes.MaterialsandMethods .Non-diabetics, newly diagnosed diabetics, and established diabetics were included. Anthropomorphic and biochemical measurements were obtained,andinsulinresistancewasapproximated.Cardiacautonomicfunctionwasassessedusingconventionalmeasuresand withpowerspectralanalysisofheartrate.ResultsandDiscussion.Heartratevariabilitywasreducedinalldiabetics.Interleukin- 6washigherindiabetics,aswasthehighmolecularweightadiponectin-to-leptinratio.Interleukin-6correlatednegativelywith measuresofautonomicbalance.Ratiosofadiponectintoleptincorrelatedpositivelywithmeasuresofautonomicbalance.Cardiac autonomicimbalanceandin?ammationoccurearlyindiabetesandareinterrelated.Conclusions.Cardiacautonomicimbala