Cell Replication and Angiogenesis in Central Nervous System Tumors and Their Relationship with the Expression of Tissue Prolactin and Hyperprolactinemia英文文献资料.docVIP

Open Journal of Pathology, 2012, 2, 50-57 Published Online July 2012 (http://www.SciRP.org/journal/ojpathology) /10.4236/ojpathology.2012.23011 Cell Replication and Angiogenesis in Central Nervous System Tumors and Their Relationship with the Expression of Tissue Prolactin and Hyperprolactinemia Denise M. D. Abech, Júlia F. S. Pereira-Lima, Carolina G. S. Le?es, Rosalva T. Meurer, Lígia M. Barbosa-Coutinho, Nelson P. Ferreira, Miriam C. Oliveira * Center for Neuroendocrinology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil. * Email: mco@.br Received April 19 , 2012; revised May 11 , 2012; accepted May 24 , 2012 th th th ABSTRACT This study aimed to assess the effect of intracellular prolactin (ICPRL) and hyperprolactinemia on cell replication, using an immunohistochemical (IHC) technique for Ki-67 and Mcm-2, and angiogenesis, using IHC for endoglin CD-105, in central nervous system (CNS) tumors. This cross-sectional study included 79 cases of surgically excised primary CNS tumors of neuroepithelial origin (41.8% of all cases: 10.2% astrocytomas, 24% glioblastomas and 7.6% oligodendro- gliomas) and meningeal origin (58.2% of all cases). Ki-67 and Mcm-2 indexes were calculated as a percentage of marked cells. The medians for Ki-67 and Mcm-2 indexes were significantly lower in meningiomas than in glioblas- tomas (p 0.001 for Ki-67 and p 0.001 for Mcm-2) and oligodendrogliomas (p 0.001 for Ki-67 and p = 0.02 for Mcm-2). A good correlation was observed between the Ki-67 and Mcm-2 (rS = 0.60) replication markers. There were no significant differences in vascular density between the different histological types. Immunohistochemistry for ICPRL was positive in 45.6% of the tumors. Serum prolactin (PRL) was elevated in 30.6% of the cases. Multiple re- gre