Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates 英文参考文献.docVIP

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Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates 英文参考文献.doc

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Evolutionary Dynamics of the Interferon-Induced Transmembrane Gene Family in Vertebrates 英文参考文献

EvolutionaryDynamicsoftheInterferon-Induced TransmembraneGeneFamilyinVertebrates ZhaoZhang1,2,3,JunLiu1,MengLi1,HuiYang2*,ChiyuZhang1,3* 1InstituteofLifeSciences,JiangsuUniversity,Jiangsu,China,2StateKeyLaboratoryofGeneticResourcesandEvolution,KunmingInstituteofZoology,ChineseAcademy ofSciences,Kunming,China,3Diagnosticcenterforpathogens,InstitutPasteurofShanghai,ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofSciences, Shanghai,China Abstract Vertebrate interferon-induced transmembrane (IFITM) genes have been demonstrated to have extensive and diverse functions,playingimportantrolesintheevolutionofvertebrates.Despiteobservanceoftheirfunctionality,theevolutionary dynamicsofthisgenefamilyarecomplexandcurrentlyunknown.Here,weperformeddetailedevolutionaryanalysesto unravel the evolutionary history of the vertebrate IFITM family. A total of 174 IFITM orthologous genes and 112 pseudogenes were identified from 27 vertebrate genome sequences. The vertebrate IFITM family can be divided into immunity-related IFITM (IR-IFITM), IFITM5 and IFITM10 sub-families in phylogeny, implying origins from three different progenitors.Ingeneral,vertebrateIFITMgenesarelocatedintwoloci,onecontainingtheIFITM10gene,andtheotherlocus containing IFITM5 and various numbers of IR-IFITM genes. Conservation of evolutionary synteny was observed in these IFITMgenes.SignificantfunctionaldivergencewasdetectedamongthethreeIFITMsub-families.Nogeneduplicationor positiveselectionwasfoundinIFITM5sub-family,implyingthefunctionalconservationofIFITM5invertebrateevolution, which is involved in bone formation. No IFITM5 locus was identified in the marmoset genome, suggesting a potential associationwiththetinysizeofthismonkey.TheIFITM10sub-familywasdividedintotwogroups:aquaticandterrestrial types.Functionaldivergencewasdetectedbetweenthetwogroups,andfiveIFITM10-likegenesfromfrogweredispersed intothetwogroups.BothgeneduplicationandpositiveselectionwereobservedinaquaticvertebrateIFITM10-likegenes, indicatin