Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores 英文参考文献.docVIP

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Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores 英文参考文献.doc

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Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores 英文参考文献

Available online /content/10/2/R39 Research article Open Access Vol 10 No 2 Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores R Andrew Moore1, Owen A Moore2, Sheena Derry1 and Henry J McQuay1 1Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Oxford OX3 7LJ, UK 2Department of Rheumatology, Musgrove Park Hospital, Stockmans Lane, Belfast BT0 7JB, UK Corresponding author: R Andrew Moore, andrew.moore@pru.ox.ac.uk Received: 6 Feb 2008 Revisions requested: 14 Mar 2008 Revisions received: 27 Mar 2008 Accepted: 2 Apr 2008 Published: 2 Apr 2008 Arthritis Research Therapy 2008, 10:R39 (doi:10.1186/ar2394) This article is online at: /content/10/2/R39 ? 2008 Moore et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Osteoarthritis trials usually report average Results With placebo, the proportions of patients achieving at least 20%, 50% and 70% pain relief over baseline at 6 weeks were 30%, 11% and 2%. With 60 mg etoricoxib the equivalent percentages were 74%, 49% and 29%. The numbers needed to treat for 30 mg and 60 mg etoricoxib to produce at least 50% pain relief at 6 weeks compared with placebo were 4.2 (95% confidence interval 3.8 to 8.6) and 2.6 (2.0 to 3.9), respectively. Levels of pain relief of 50% and above discriminated best between different doses of etoricoxib. changes in visual analogue scale (VAS) pain, and examine the difference between treatment and placebo. We investigated whether dichotomous responder analysis provides a more informative interpretation of drug efficacy. Methods Merck supplied the number of patients who,