Objectively Measured Physical Activity and Fat Mass in Children A Bias-Adjusted Meta-Analysis of Prospective Studies 英文参考文献.docVIP

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Objectively Measured Physical Activity and Fat Mass in Children A Bias-Adjusted Meta-Analysis of Prospective Studies 英文参考文献.doc

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Objectively Measured Physical Activity and Fat Mass in Children A Bias-Adjusted Meta-Analysis of Prospective Studies 英文参考文献

ObjectivelyMeasuredPhysicalActivityandFatMassin Children:ABias-AdjustedMeta-AnalysisofProspective Studies DesireeC.Wilks1,2,StephenJ.Sharp3,UlfEkelund3*,SimonG.Thompson4,AdrianP.Mander4, RebeccaM.Turner4,SusanA.Jebb1,AnnaKarinLindroos1 1Medical Research Council Collaborative Centre for Human Nutrition Research, Cambridge, United Kingdom, 2Department of Prevention and Sports Medicine, TechnischeUniversita¨t Mu¨nchen,Germany,3MedicalResearchCouncilEpidemiologyUnit,Cambridge,UnitedKingdom, 4MedicalResearchCouncilBiostatisticsUnit, Cambridge,UnitedKingdom Abstract Background:Studiesinvestigatingthepreventionofweightgaindifferconsiderablyindesignandquality,whichimpedes poolingtheminconventionalmeta-analyses,thebasisforevidence-basedpolicymaking.Thisstudyisaimedatquantifying theprospectiveassociationbetweenmeasuredphysicalactivityandfatmassinchildren,usingameta-analysismethodthat allowsinclusionofheterogeneousstudiesbyadjustingfordifferencesthroughelicitingandincorporatingexpertopinion. Methods:Studiesonpreventionofweightgainusingobjectivelymeasuredexposureandoutcomewereeligible;theywere adoptedfromarecentlypublishedsystematicreview.Differencesinstudyqualityanddesignwereconsideredasinternal and external biases and captured in checklists. Study results were converted to correlation coefficients and biases were consideredeitheradditiveorproportionalonthisscale.Theextentanduncertaintyofbiasesineachstudywereelicitedina formal process by six quantitatively-trained assessors and five subject-matter specialists. Biases for each study were combinedacrossassessorsusingmedianpooling.Resultswerecombinedacrossstudiesbyrandom-effectsmeta-analysis. Results: The combined correlation of the unadjusted results from the six studies was 20.04 (95%CI: 20.22, 0.14) with considerable heterogeneity (I2=78%), which makes it difficult to interpret the result. After bias-adjustment the pooled correlationwas20.01(95%CI:20.18,0.16)withapparentstudycompatibility(I2 =0%). Conclusion: By using