Organophosphate Poisoning–Induced Intermediate Syndrome Can Electrophysiological Changes Help Predict Outcome 英文参考文献.docVIP

Perspective Organophosphate Poisoning–Induced Intermediate Syndrome: Can Electrophysiological Changes Help Predict Outcome? Cynthia K. Aaron O rganophosphate (OP) pesticides contribute to a substantial burden of mortality and morbidity from self- poisoning, particularly in developing countries. Such poisonings are Electrophysiological Recordings in Organophosphate Poisoning: The New Study Linked Research Article This Perspective discusses the following new study published in PLoS Medicine: In the paper published in PLoS Jayawardane P, Dawson AH, Weerasinghe V, Karalliedde L, Buckley NA, et al. (2008) The spectrum of intermediate syndrome following acute organophosphate poisoning: A prospective cohort study from Sri Lanka. PLoS Med 5(7): e147. doi:10.1371/journal.pmed.0050147 Medicine [1], the researchers describe results of a prospective observational study of 78 patients with symptomatic OP poisoning presenting to two associated with several syndromes, including acute cholinergic crises, the intermediate syndrome (IMS), and organophosphate-induced delayed neuropathy. In a study published in PLoS Medicine, Jayawardane and colleagues begin to scientifically characterize a specific constellation of signs and symptoms seen after poisoning with organophosphates [1]. Specifically, they aim to define the pathophysiology of IMS, which was initially described in 1987 as an illness occurring after the resolution of acute cholinergic crises and associated with proximal muscle weakness [2]. Since this seminal article was published, there has been tremendous controversy in the toxicology world concerning the true definition and existence of IMS as an isolated entity [3,4]. Here, Jayawardane and colleagues further elucidate the nature of IMS by systematically recording repetitive nerve stimulation (RNS) patterns at the neuromuscular junction in patients poisoned with OPs. hospitals in the Central Province of Sri Lanka between May 2005 and December 2006. All patients were trea