Pregnant women become insensitive to cold stress 英文参考文献.docVIP

BMC Pregnancy and Childbirth BioMedCentral 2 Research aandrticChildbirthle Open Access BMC2002Pregnancy, x Pregnant women become insensitive to cold stress Martin Kammerer?1, Diana Adams?2, Brida von Castelberg?3 and Vivette Glover?*2 Address: 1c/o University of Zurich, KJPD, Regionalstelle Horgen, Bahnhofstr.6, CH 8810 Horgen, Switzerland, 2Wolfson and Weston Research Centre for Family Health, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK and 3Klinik für Gyn?kologie und Geburtshilfe, Maternité Inselhof Triemli, Birmensdorferstr.501, CH 8063 Zürich, Switzerland E-mail: Martin Kammerer - makam1@bluewin.ch; Diana Adams - diana.adams@ic.ac.uk; Brida von Castelberg - makam1@bluewin.ch; Vivette Glover* - v.glover@ic.ac.uk *Corresponding author ?Equal contributors Published: 19 November 2002 Received: 26 July 2002 Accepted: 19 November 2002 BMC Pregnancy and Childbirth 2002, 2:8 This article is available from: /1471-2393/2/8 ? 2002 Kammerer et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: The function of the hypothalamic-pituitary-adrenal (HPA) axis is known to be altered during pregnancy, but it has not been tested with a natural stressor. Methods: A group of pregnant women (n = 10) were tested towards the end of pregnancy (mean 36.8 ± 2.5 weeks gestation) and about 8 weeks postpartum (mean 7.8 ± 1.5 weeks), together with a matched control group, with a one minute cold hand stressor test. Saliva samples were collected before and 10 and 20 minutes after the test, and stored for later radioimmunoassay of cortisol. Results: The control group showed a highly significant response to the test. The pregnant group showed no response, and