Research Upregulation of CD23 (FcεRII) Expression in Human Airway Smooth Muscle Cells (huASMC) in Response to IL-4, GM-CSF, and IL-4GM-CSF 英文参考文献.docVIP

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Research Upregulation of CD23 (FcεRII) Expression in Human Airway Smooth Muscle Cells (huASMC) in Response to IL-4, GM-CSF, and IL-4GM-CSF 英文参考文献.doc

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Research Upregulation of CD23 (FcεRII) Expression in Human Airway Smooth Muscle Cells (huASMC) in Response to IL-4, GM-CSF, and IL-4GM-CSF 英文参考文献

Clinical and Molecular Allergy BioMedCentral Research Open Access Research Upregulation of CD23 (FcεRII) Expression in Human Airway Smooth Muscle Cells (huASMC) in Response to IL-4, GM-CSF, and IL-4/GM-CSF Joseph T Belleau?, Radha K Gandhi?, Holly M McPherson and D Betty Lew* Address: Department of Pediatrics, Childrens Foundation Research Center at the Le Bonheur Childrens Medical Center, University of Tennessee Health Science Center, 50 North Dunlap Street, Rm401, WPT, Memphis, TN 38103, USA Email: Joseph T Belleau - jcbelleau@; Radha K Gandhi - rgandhi@; Holly M McPherson - HMCPHERSON@PIEDMONTALLERGY.COM; D Betty Lew* - dlew@ * Corresponding author ?Equal contributors Published: 20 May 2005 Received: 30 August 2004 Accepted: 20 May 2005 Clinical and Molecular Allergy 2005, 3:6 doi:10.1186/1476-7961-3-6 This article is available from: /content/3/1/6 ? 2005 Belleau et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Airway smooth muscle cells play a key role in remodeling that contributes to airway hyperreactivity. Airway smooth muscle remodeling includes hypertrophy and hyperplasia. It has been previously shown that the expression of CD23 on ASMC in rabbits can be induced by the IgE component of the atopic serum. We examined if other components of atopic serum are capable of inducing CD23 expression independent of IgE. Methods: Serum starved huASMC were stimulated with either IL-4, GM-CSF, IL-13, IL-5, PGD2, LTD4, tryptase or a combination of IL-4, IL-5, IL-13 each with GM-CSF for a period of 24 h. CD23 expression was analyzed by flow cytometry, western blot, and indirect immunofluorescence. Results: The CD23 protein expression was upregulated in huASMC in response to IL-4, GM-CS