Secondary Metabolites from Inula britannica L. and Their Biological Activities 英文参考文献.docVIP

Molecules 2010, 15, 1562-1577; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Secondary Metabolites from Inula britannica L. and Their Biological Activities Abdul Latif Khan 1,2, Javid Hussain 2, Muhammad Hamayun 1, Syed Abdullah Gilani 4, Shabir Ahmad 2, Gauhar Rehman 3, Yoon-Ha Kim 1, Sang-Mo Kang 1 and In-Jung Lee 1,* 1 School of Applied Biosciences, Kyungpook National University, Korea 2 Department of Chemistry, Kohat University of Science Technology, Kohat, Pakistan 3 Department of Genetic Engineering, School of Life Sciences Biotechnology, Kyungpook National University, Korea 4 Department of Biotechnology, Kohat University of Science Technology, Kohat, Pakistan * Author to whom correspondence should be addressed; E-Mail: ijlee@knu.ac.kr; Tel.: +82-53 950 5708. Received: 4 January 2010; in revised form: 25 January 2010 / Accepted: 28 January 2010 / Published: 10 March 2010 Abstract: Inula britannica L., family Asteraceae, is used in traditional Chinese and Kampo Medicines for various diseases. Flowers or the aerial parts are a rich source of secondary metabolites. These consist mainly of terpenoids (sesquiterpene lactones and dimmers, diterpenes and triterpenoids) and flavonoids. The isolated compounds have shown diverse biological activities: anticancer, antioxidant, anti-inflammatory, neuroprotective and hepatoprotective activities. This review provides information on isolated bioactive phytochemicals and pharmacological potentials of I. britannica. Keywords: I. britannica; sesquiterpenoids; flavonoids; triterpenoids; anticancer; antioxidant; anti-inflammatory; hepatoprotective; neuroprotective 1. Introduction The genus Inula (Asteraceae) is known for diverse biological activities, i.e., anticancer, antibacterial, hepaprotective, cytotoxic, and anti-inflammatory properties [1]. It comprises