Sequencing the regulatory genome 英文参考文献.docVIP

Meeting report Sequencing the regulatory genome Stein Aerts* and Stefanie Butland? Addresses: *Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven B-3000, Belgium. ?Centre for Molecular Medicine and Therapeutics, CFRI, University of British Columbia, Vancouver, V5Z 4H4, Canada. Correspondence: Stefanie Butland. Email: butland@cmmt.ubc.ca Published: 19 June 2008 Genome Biology 2008, 9:313 (doi:10.1186/gb-2008-9-6-313) The electronic version of this article is the complete one and can be found online at /2008/9/6/313 ? 2008 BioMed Central Ltd increasing number of laboratories, the regulatory geography A report on the Cold Spring Harbor Laboratory meeting of the genome is now being assessed within the three- ‘Systems Biology: Global Regulation of Gene Expression’, dimensional context of the nucleus. Cold Spring Harbor, USA, 27-30 March 2008. Bas van Steensel (Netherlands Cancer Institute, Amsterdam, the Netherlands) provided an elegant picture of human gene The line between the biological and computational research communities has disappeared in the field of gene regulation. The group of regulatory biology researchers represented at the recent meeting at Cold Spring Harbor on systems biology shares the same goal: develop and apply experimental and computational technologies to decipher the genomic regula- tory code and the gene regulatory networks that are the driving forces of development and evolution. As in previous years, important gaps in solving the complex problem of gene regulation were bridged. This year featured the emer- ging massively parallel sequencing technologies, which are now being applied to every conceivable step in the gene regulation process, from gene annotation and alternative splicing, to transcription factor binding, and chromatin structure. Topics covered at the meeting ranged widely and in this re