Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes 英文参考文献.docVIP

Castoe et al. Genome Biology 2011,12:406 /2011/12/7/406 OPEN LE T TER Open Access Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes Todd A Castoe , AP Jason de Koning , Kathryn T Hall , Ken D Yokoyama , Wanjun Gu , Eric N Smith , Cédric Feschotte , 1 1 1 1 2 3 3 4 5 6 6 7 8 Peter Uetz , David A Ray , Jason Dobry , Robert Bogden , Stephen P Mackessy , Anne M Bronikowski , 9 10 1 Wesley C Warren , Stephen M Secor and David D Pollock * undergo atrophy [6]. is extreme modulation of tissue morphology and function facilitates investigation into the signaling and cellular mechanisms that underlie regu- lation of organ performance and regeneration. ese animals are also readily obtained from commercial breeders, non-aggressive, and easier and cheaper to care for than laboratory rats. e scienti?c potential of this system to reveal molecular mechanisms associated with these extreme reactions (and their reversal) is tremen dous, and can provide novel insight into vertebrate gene and systems function, novel strategies and drug targets for treating human diseases, and alternative disease models. Snakes have also been used as model species for high- pro?le discoveries pertaining to vertebrate development, Abstract The