Unipolar late-onset depression A comprehensive review 英文参考文献.docVIP

Annals of General Hospital Psychiatry BioMedCentral Review Open Access Unipolar late-onset depression: A comprehensive review Konstantinos N Fountoulakis*1, Ruth OHara2, Apostolos Iacovides1, Christopher P Camilleri2, Stergios Kaprinis1, George Kaprinis1 and Jerome Yesavage2 Address: 13rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece and 2Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford California U.S.A Email: Konstantinos N Fountoulakis* - kfount@med.auth.gr; Ruth OHara - roh@; Apostolos Iacovides - kfount@med.auth.gr; Christopher P Camilleri - roh@; Stergios Kaprinis - kaprinis@med.auth.gr; George Kaprinis - kaprinis@med.auth.gr; Jerome Yesavage - yesavage@ * Corresponding author Published: 16 December 2003 Received: 01 February 2003 Accepted: 16 December 2003 Annals of General Hospital Psychiatry 2003, 2:11 This article is available from: /content/2/1/11 ? 2003 Fountoulakis et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Depressionpsychogeriatricslate-lifeSSRIsTCAspsychotherapy Abstract Background: The older population increases all over the world and so also does the number of older psychiatric patients, which manifest certain specific and unique characteristics. The aim of this article is to provide a comprehensive review of the international literature on unipolar depression with onset at old age. Methods: The authors reviewed several pages and books relevent to the subject but did not search the entire literature because of its overwhelming size. They chose to review those considered most significant. Results: The prevalence of major depression is estimated to be 2% in the general population over 65 years of age. The clinical picture of geriatric depres