Unloading work of breathing during high-frequency oscillatory ventilation a bench study 英文参考文献.docVIP

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Unloading work of breathing during high-frequency oscillatory ventilation a bench study 英文参考文献.doc

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Unloading work of breathing during high-frequency oscillatory ventilation a bench study 英文参考文献

Available online /content/10/4/R103 Research Open Access Vol 10 No 4 Unloading work of breathing during high-frequency oscillatory ventilation: a bench study Marc van Heerde1, Karel Roubik2, Vitek Kopelent2, Frans B Pl?tz1 and Dick G Markhorst1 1Department of Pediatric Intensive Care, VU University Medical Center, Amsterdam, The Netherlands 2Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic Corresponding author: Marc van Heerde, m.vanheerde@vumc.nl Received: 20 Apr 2006 Revisions requested: 8 Jun 2006 Revisions received: 14 Jun 2006 Accepted: 22 Jun 2006 Published: 18 Jul 2006 Critical Care 2006, 10:R103 (doi:10.1186/cc4968) This article is online at: /content/10/4/R103 ? 2006 van Heerde et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction With the 3100B high-frequency oscillatory inspiratory imposed WOB by 30% to 56% and inspiratory imposed PTP by 38% to 59% compared to continuous fresh gas flow. Expiratory imposed WOB was decreased as well by 12% to 49%. In simulations of shallow to normal breathing for an adult, imposed WOB is 0.5 J l-1 at maximum. Fluctuations in mean airway pressure on account of spontaneous breathing are markedly reduced. ventilator (SensorMedics, Yorba Linda, CA, USA), patients spontaneous breathing efforts result in a high level of imposed work of breathing (WOB). Therefore, spontaneous breathing often has to be suppressed during high-frequency oscillatory ventilation (HFOV). A demand-flow system was designed to reduce imposed WOB. Methods An external gas flow controller (demand-flow system) accommodates the ventilator fresh gas flow during spontaneous breathing simulation. A control algorithm de