血浆脂联素水平与冠心病的相关性.pdfVIP

《东南国防医药~2007年12月第9卷第6期 ● 论 著 ● 血浆脂联素水平与冠心病的相关性 尹 炯 ，潘晓明 (1．解放军第85医院心内科，上海 200052；2．上海长征医院心内科，上海 200052) [摘 要] 目的 观察冠心病患者血浆脂联素水平，并探讨血浆脂联素水平与冠心病间的关系。方法 经冠状动脉造影证实的冠 心病患者共219例，对照组187例，采用Adiponectin ELISA试剂盒检测血浆脂联素水平，检测空腹血糖(Bs) 总胆固醇(Tc) 甘{珏i 三酯(TG)、低密度脂蛋白胆固醇(LDL—c)、高密度脂蛋白胆固醇(HDL—c)；计算体重指数。结果 冠心病组患者的脂联素水平(6．3 VS 12．6，P0．01)显著低于对照组；Spearman偏相关分析显示经年龄、性别校正后脂联素水平与BS、SBP、LDL—C、TG呈负相关， 与HDL—C呈正相关；多元logistic回归分析显示脂联素水平与冠心病及其主要危险因子独立相关。结论 冠心病患者血浆脂联素水 平降低，可能是冠心病的一个新的独立危险因子。 [关键词] 脂联素；冠心病 ；危险因子 中图分类号： R541．4 文献标识码： A 文章编号： 1672—271X(2007)06—0403—03 Plasma adiponectin concentrations correlated with coronary heart disease YIN Jiong ，PAⅣXiao—ming (1．Department ofCardiovasology，the 85th Hospital ofPLA，Shanghai 200052，China；2．Depart— ment of Cardiovasology，Shanghai Changzheng Hospital，Shangha 200052，China) [Abstract] Objective To test plasma adiponectin concentrations of coronary heart disease(CHD)patients and evaluate whether plasma adiponectin coneetrations were associated with CHD． Methods Plasma adiponectin concentrations were measured using adiponectin ELISA kit in 219 casese CHD patients confirmed by coronary angiography and 187 casese angiographical1y negati ve pa - tients．Plasma concentrations of fasting blood sugar(BS)，total cholesterol(TC)，triglycerin(TG)，low density lipoprotein tholes— terol(LDL—C)and high density lipoprotein cholesterol(HDL—C)were measured by routine method．Body mass index was calculated Results Plasma adiponectin concentrations in CHD patients wefe significantly lower than those in the control subjects．Spearman partial correlation analysis showed that adiponectin was significantly negatively correlated with BS，systolic blood pressure，LDL—C and TG，and positively correlated with HDL～C after adjustment for age and sex．Multiple logistic regression analysis showed tha