血清CA19-9、CEA水平与意外胆囊癌转移的关系研究.pdfVIP

· 868· 200己 11月第22卷第11期 Chin J Gen su ，November 2oo7．vo1．22．No．11 ． 论著 血清CA1 9—9、CEA水平与意外 胆囊癌转移的关系研究 陆卫军 张柏和 沈阳 李殿启 【摘要】 目的 探讨意外胆囊癌转移与血清CA19-9、CEA水平的关系。方法 对2002年8月 至2006年6月收治的60例意外胆囊癌患者的临床资料进行回顾性分析，将血清CEA≥10 ng／ml及 CA19-9137 U／ml者做为异常(阳性组)，组问比较采用X2检验，P0．05为差异有统计学意义。 结果 35例(58％，35／60)意外胆囊癌再手术后发现肿瘤转移。CA19-9阳性组及CA19-9阴性组肿 瘤转移率分别为93％(27／29)及26％(8／31)，两组比较差异有统计学意义(P0．05)；CEA阳性组 及CEA阴性组肿瘤转移率分别为92％(12／13)及49％(23／47)，两组比较差异有统计学意义(P 0．05)。 结论 意外胆囊癌转移率与血清CA19-9及CEA水平有关，CA19-9可用于术前判断意外胆 囊癌转移，与CEA联合应用可以提高诊断准确率。 【关键词】胆囊肿瘤；肿瘤转移；CA19-9；CEA Prediction 0f preoperative neoplasm metastasis in patients with unexpected gallbladder carcinoma by determination of serum CA19-9 and CEA levels，report of 60 cases LU Wei-jun，ZHANG Bai—he， SHENG ，12 Dian—qi．Department ofBiliary Surgery 1，Eastern Hepatobiliary Surgery Hospital，Second Military Medical University，Shanghai 200438，China Corresponding author：LU Wei-jun，E—mail：1wjwmltg@sohu．com 【Abstract】 Objective To evaluate the prediction of preoperative neoplasm metastasis of unexpected gallbladder carcinoma(UGC)by the measurement of serum CA19-9 and CEA levels． Methods Clinical data of 60 cases of UGC from 2002．8—2006．6 were retrospectively analyzed．CEA≥10 ng／ml and CA19-9 I37 U／ml were defined as abnorma1．X was used and a P value less than 0．05 Was regarded as significant． Results The neoplasm metastasis rate of UGC accounted for 58．3％(35／60)as found by following surgery．Neoplasm metastasis was 93％(27／29)in patients with CA19-9(+)as compared with 26％(8／31)in those with CA19-9(一)patients(P0．05)；The neoplasm metastasis rate of CEA(+) and CEA(一)group were 92％(12／13)and 49％(23／47)respectively(P0．05)． Conclusions In cases of unexpected gallbladder carcinoma，abnormally high level of serum CA19-9 and CEA concentration may predict a cancer matastasis． 【Key words】 Gallbladder neoplasms；Neopl