ICA方法与NIR技术用于药片中活性成分含量的测定.pdfVIP

2∞8 年第 66 卷 化学学报 Vol. 66, 2∞8 第 15 期， 1791-1795 ACfA CHIMICA S阳ICA No. 15, 1791-1795 ·研究论文· ICA 方法与 NIR 技术用于药片中活性成分含量的测定 林敏* 方利民 (中周计最学院计最测试工程学院 杭州 31∞18) 摘要 用独JL分最分析(ICA)方法提取药片近红外光谱数据矩阵的独立成分和相应的混合矩阵，再用 BP 神经网络对混 合矩阵和药片中活性成分的浓度矩阵进行建模提出了新的药片惰性成分含量测定的基于独立分量分析…神经网络回 归(ICA-NNR)的近红外光谱分析方法.通过分析独立分肇数和网络中间隐居的神经元数对模型性能的影响，分别建立 三类药片定最分析的最优模型.该方法用于实测的豆类药片中洁性成分食景的测定，测试样品集的化学检测值与近红 外预测值的相关系数分别达到0.962， 0.980 及0.979. 结果表明，基于ICA州R 的近红外光谱分析方法对制商业的药片 道行定盘分析是可行的. 关键词 独立分量分析;神组网络凹归;近红外光谱;药片 Prediction of Active Substance Contents in Pharmaceutical 丁ablet Using ICA and NIR FANG , Li-Min LIN , Min中 (College 01Metrolo.盯Measurement and Engineering , China Jíliang Universi纱， Hangzhou 311阳的 Abstract A new method of model prediction of active substance contents in pharmaceutical tablet based on near-infrared spectroscopy (NIR) , artificial neural network regression (NNR) and independent component analysis (lCA) w邸 proposed. In its application to tablet near-infrared spectroscopy, the independent com翩 ponents and the mixing matrix were firstly extracted by ICA. And then , the model of the mixing matrix and active substance content matrix was built by the BP NNR. The influence of the numbers of independent components and the neurons in the hidden layer on the prop创ies of the model was further discussed , and three classes of tablet optimal quantitative制analysis models were built respectively. This new chemometric method has been applied to the prediction of active substance contents in three classes