直肠癌患者术前替加氟局部肛栓对T淋巴细胞亚群的影响.pdfVIP

2007年 l2月 第 l1卷 第 6 411 [文章编号]1009—2188(2007)06—0411—02 · 临 床 论 著 · 直肠癌患者术前替加氟局部肛栓 对T淋巴细胞亚群的影响 王智，刘博，史景峰 (辽宁鞍山市中心医院，鞍山114001) [摘要] 目的 探讨替加氟局部肛栓对直肠癌患者T淋巴细胞亚群的影响。 方法 54例直肠癌患 者，30例(试验组)手术前行替加氟局部肛栓化疗，500 mg／次，2次／d，共14 d。24例(对照组)术前未 行化疗。 结果 试验组化疗结束及术后1周的CD+4／CD+8较化疗前明显提高，有显著性差异(P 0．05)。两组手术后1周与手术前比较各项指标均较手术前无显著性差异；手术后组间比较亦无显著差 异(P0．05)。 结论 直肠癌患者术前替加氟栓局部肛栓化疗能改善免疫状态，是一种安全、有效、 方便的给药途经。 [关键词] 直肠肿瘤； T淋巴细胞亚群； 栓剂 [中图分类号]R735．37 [文献标识码]B Effect on T-lymphocyte Subsets of Preoperative Intrarectal Administration of Tegafur Emulsion in Rec- tal Cancer WANG Zhi，LIU Bo，SHI~ng-feng (Department of General Surgery，Central Hospital ofArts— han，Anshan 1 14001，Liaoning，C^ina) Abstract： Objective To investigate of the changes of T—lymphocyte subsets of preoperative intrareetal administration of tegafur emulsion in rectal cancer． Methods 54 rectal cancer patients were underwent radi— cal resection．Among them，30 cases ranged as experiment group were added local chemotherapy preoperatively by intrareetal administration with tegafur emulsion，with a dosage of 500 mg per time，Bid for 14 days．The oth— er 24 cases were ranged as control group、 Results In experiment group．the level of CD+4／CD+8 Was ob— viously increasing at the end of chemotherapy and 1一week after the operation than that of pre—chemotherapy(P 0．05)． Conclusion Preoperative intrareetal administration of tegafur emulsion can improve the immune state for rectal cancer，and regards a safe，effective and convenient administration approach． Key words： rectal neoplasms； T—lymphocyte subsets； suppositories 直肠癌是常见的消化道肿瘤，各种根治性手术 前替加氟栓(成都第一制药)局部肛栓给药，观察直 后5年生存率在50％左右…。采用术前化疗等综 肠癌病人化疗前后及手术前后T淋巴细胞亚群的 合治疗方法，可以提高大肠癌的疗效已得到许多学 变化，评价替加氟栓局部肛栓化疗的效果如下。 者的共识。术前化疗的方式和途径正逐渐受到临床