血小板源性生长因子-C在子痫前期、子痫患者胎盘的表达.pdfVIP

现代妇产科进展2007年12月第16卷第12期 Prog Obstet Gynecol，Dec．2oo7，Vo1．16，No．12 · 论著 · 血小板源性生长因子一C在子痫前期、子痫 患者胎盘的表达 杨 茵，葛 榕，孙 阳 (福建医科大学省立临床学院，福建省立医院妇产科，福州 350001) 【摘要】 目的：通过比较正常妊娠和子痫前期、子痫患者胎盘组织的血小板源性生 长因子一C(PDGF—C)mRNA表达，探讨PDGF—C与子痫前期、子痫发病的关系。方法：采用 逆转录聚合酶链反应(RT—PCR)检测43例子痫前期、子痫患者和20例正常孕妇胎盘绒毛 组织PDGF—CmRNA的表达。结果：PDGF—C mRNA在正常妊娠胎盘组织母体面中仅有少 量表达，在子痫前期、子痫患者胎盘母体面中表达则明显增多(P0．01)，且表达量与疾 病的严重程度呈正相关。结论：PDGF—C在子痫前期、子痫患者胎盘高度表达，可能在子 痫前期、子痫患者胎盘血管病变中起着重要作用，并参与子痫前期、子痫的发生和发展。 【关键词】 血小板源性生长因子；子痫前期；子痫；动脉硬化 中图分类号：R714。24 4 文献标识码：A 文章编号：1004-7379(2007)12—0905—03 E ression of platelet-derived growth factor-C mRNA in placenta from patients witll preedampsia or eclampsia． ng n， 舶ng，Sun ng．Provincial Clinical Institute of Fu- iian Medical Unive~ity，Department of Gynecology and Obstetrics，Fuiian Provincial Hospital， Fuzhou 350001 【Abstract】 Objective：To investigate the expression of platelet—derived growth factor—C mRNA in placentas from patients with preeclampsia or eclampsia and its significance．Method： rI1le mRNA expression levels of PDGF—C were determined using RT—PCR in the placentas of 20 ea~es of normal pregnant women and of 43 cases of patients with preeclampsia or eclampsia．Re- suit：The mRNA expression levels of PDGF．C in the patients with preeelampsia or eelampsia were significantly higher than those in the normal pregnancy group(P0。O1)，and were posi— tively correlated with the degree of the disease。Conclusion：Patients with preeclampsia or ee· lampsia have higher expression levels of PDGF—C in the placentas，which may play an important role in the development of preeclampsia or eclampsia by promoting atherogenesis in the placen— tal vessels． 【Key words] Platelet—derived growth factor；Pre—eclampsia；Eclampsia；Arteroselerosis 子痫前期、子痫是孕期以高血压为主要特征的 标准参见《妇产科学》第6版 。另选取年龄和孕周匹配的 多系统疾病，严重威胁母婴健康。其特征性病理改 正常孕妇20例作为对照组。所有病例均除外其