血清MMPs水平在腹腔镜大肠癌根治中表达的临床意义.pdfVIP

584 Chin J Hemorh ．2007；1 7(4) 血清MMPs水平在腹腔镜大肠癌根治中表达的临床意义 王 彤，窦慧强，姜秀峰，周 雄，胡行前 (无锡市第一人民医院，汀苏无锡 214002) 摘要：目的 通过对同手术期腹腔镜手术 常规手术时检测患者血清中基质金属蛋白酶(MMP．9)在大肠癌患者血清中 水平表达的比较．探讨C02气腹环境下是否会增加肿瘤根治的风险性。方法 64例大肠癌患者随机分为开腹~dA(32例)， 腹 腔镜组(32例)及32例结肠息肉患者(对照组)，于手术前后选择不同时段应用ELISA法检测血清中MMP．9的改变。结果 大 肠癌患者血清中MMP-9的水平 著高于对照组(尸O．01)．腹腔镜组也明 高于开腹组(尸O．05)。结论 LC手术中C0 气 腹环境下尽管不会增加肿瘤根治的风险性，但是其疗效的确定还有赖于更多的研究和长 随访。 关键词：MMP．9；腹腔镜；大肠癌 中图法分类号：R657．4 文献标识码：A 文章编号：1009—881X(2007)04—0584—02 The Clinical Significance of the Serum Levels of Matrix Metall0pr0teinases in Patients with Laparoscopic Operation in Colorectal Tumor WANG Tong,DOUHui—qiang,JIANG娜甜 ng,etal (Wuxi People’S Hospital，Wuxi 214002，China) Abstract：Objectives To investigate the serum of matrix metalloproteinases一9(MMP一9)of the risk of laparoscopic operation in eolorectal tBmor．Methods The 64 patients were divided into 2 groups to accept open surgical(n=32)，laparoscopic group(n 32)and 32 patients with colon polyps accept open surgical as control group respectively．Perioperative allerations of peripheral blood were compared the MMP一9 in the ELISA method exami— nation serum between the two groups．Results In colorectal tumor sufferer，the MMP一9 in the serum levels show~ significantly higher than in matched control(PO．0 1)，laparoscopic group is also significantly higher in open surgi— cal group(PO．05)．Conclusion The C02 pneumoperitoneum environment descends in the LC though it will not increase the risk for cure．Its curative effect reguires more researches and long—term follow—up investigation． Key words：matrix metalloproteinases．9；laparoscope；colorectal tumor 近年来，人们对肿瘤的侵袭性生长和转移的特 指征、可获根治性切除的结直肠癌患者。入选的64 点进行了广泛的研究，发现基质金属蛋