化合物LJZ对小鼠移植瘤生长和荷瘤小鼠免疫功能的影响.pdfVIP

昆明 医学院学报 2007，【6)：29—32 CN 53—1O49／R Journal of Ktmming Medical College 化合物LJZ对小鼠移植瘤生长和荷瘤小鼠免疫功能的影响 张雁丽”，李彩霞 ，金俞希”，卿 晨 (1)昆明医学院云南省天然药物药理重点实验室，云南昆明 650031；2)昆明医学院第一附 属医院临床实验中心，云南昆明650032) [摘要]目的 研究化合物Uz的体内抗肿瘤活性和对荷瘤小鼠免疫功能的影响．方法 以小鼠移植性肉 瘤S180和小鼠移植性肝癌H22为模型，研究化合物UZ对肿瘤生长的影响；采用DNFB诱导荷瘤鼠迟发型超 敏性反应 (DTH)反应，检测化合物Uz对荷瘤小鼠特异性免疫功能的影响；采用荷瘤小鼠腹腔巨噬细胞吞噬 中性红试验，检测化合物Uz对荷瘤小鼠非特异性免疫功能的影响．结果 化合物UZ对小鼠移植性肉瘤S180 和肝癌H22的生长均有一定的抑制作用，呈现明显的量效关系．化合物Uz能明显增强荷肉瘤sl80小鼠巨噬细 胞的吞噬功能，但对DTH无明显影响．结论 化合物Uz具有一定的抗肿瘤作用，并与其增强荷瘤小鼠非特 异性免疫功能有关． [关键词]UZ；抗肿瘤；免疫功能；小鼠 [中图分类号]R965．2[文献标识码]A [文章编号]1003—4706(2007)06—0029—04 Effects of Compound LJZ on Antitumor Activity and Immune Function in Tumor Bearing Mice ZHANG Yan-Li，LI Chai-xia，JIN Yu-xi，QING Chen (J)The Key Laboratory ofPharmacologyfor Natural Products in Yunnan Province，Kunming 650031，China；2)Climical medicine Reseovrch，The 1st Affiliated Hospital Umiversity， Kunming，650032，China) [Abstract]Objective To investigate effects of compound LJZ on antitumor activity and immune function in mice bearing implanted tumor in vivo．Methods The antitumor effects on the s~coma 180(s18o)and hep~oma 22(H22)bearing in mice were evaluated by weight of tumor．The effects of compound LJZ on specific immunity function were observed by delayed—type hypersensitivity(DTH)response induced by 2，4-dinitro-1-fluorobenzene (DNFB)and the effects of compound LJZ on non—specific immunity function were studied by macrophage phagocytosing neutral red．Results Compound UZ inhibited significantly the growth of$1 80 and H22 bearing in mice，and showed dose—dependent relationship．Compound LJZ could enhance the phagocytic capacity of macrophage in bearing S180 mice．But it had no effect on DTH． C