细胞角蛋白34βE12在乳腺肿瘤中的表达及意义.pdfVIP

现代中西医结合杂志 Modern Journal of Integrated Traditional Chinese and Western Medicine 2008 Jan，17(2) ·171· 细胞角蛋白34tiE12在乳腺肿瘤中的表达及意义 赵亚新，倪仲琳，胡希宏，卢明东，郑瑾滢，郑志强 (温州医学院附属第二医院，浙江温州325027) [摘要】 目的 研究细胞角蛋白34~3E12(CK34~3E12)在乳腺肿瘤组织中的表达情况及与乳 腺癌恶性程度的关系。方法 用免疫组化方法对77例乳腺良性肿瘤和135例乳腺癌组织石蜡 标本的CK34~3E12的表达水平进行测定，统计分析CK34~3E12在乳腺良性肿瘤与乳腺癌组织中 表这的差异，同时分析CK3413E12表这情况与乳腺癌肿瘤生物学行为指标之间的关系。结果 CK3413E12在乳腺良性肿瘤组织中阳性表达率76．6％，在乳腺癌组织中阳性表达率44，4％，2组 相比有显著性差异(尸0．05)。CK3413E12的表达与乳腺癌患者的年龄、月经状态、ER、PR等均 无相关性(P0，05)；但与组织学分级、临床分期、病理类型、腋淋巴结阳性转移等指标有相关性 (P0，05)。结论 与乳腺良性肿瘤相比，乳腺癌组织中CK3413E12的阳性表达率低。CK3413E12阴性表达提示乳腺 癌预后不佳，可用于乳腺癌恶性程度和预后的判断。 [关键词] 乳腺肿瘤；免疫组化；角蛋白；预后 [中图分类号】 R737．9 [文献标识码]A [文章编号】 1008—8849(2008】02—0171—03 Expression and meaning of Cytokeratin 34 BE12 in breast tumour Zhao Yaxin，Ni Zhonglin，Hu Xihong，Lu Mingdong，Zheng Jinying，Zheng Zhiqiang (The Second Affiliated Hospital of Wenzhou Medical College，Wenzhou 325000，Zhejiang，China) Abstract：Objective It is tO study the expression of cytokeratin 34~3E12(CK34~3E12)in breast tumor tissue and the rela— tionship between CK34~3E12 expression and breast cancer malignant degree．Methods The expression levels of CK3413E12 in 77 cases of breast benign tumor tissue and 135 cases of breast cancer tissue were detected with immunohistoehemistry method．The difference of CK34~3E12 expression in breast fibroma tissue and breast cancer tissue was analyzed．And the rela． tionship between CK34[~E12 expression and the breast cancer biological parameter was also analyzed．Results The positive ex— pression rate of CK3413E12 in breast benign tumor tissue WaS 76．6％ and that in breast cancer tissue was 44．4％．and there was signifi