p53、Ki-67在弥漫性大B细胞淋巴瘤中的表达及相互关系.pdfVIP

· 914· 肿瘤防治研究2007年第34卷第12期 p53、Ki一67在弥漫性大B细胞淋巴瘤中的 表达及相互关系 张文书 ，杨庆春 ，张望望 ，刘 勇 ，路名芝 ，张文平 Expression of p53 Protein in DLBCL and Its Relationship with Expression of Ki一67 Protein ZHANG Wen-shu ，YANG Qing-chun ，ZHANG Wang-wang~，LIU Yon ，LU Ming-zhi3，ZHANG Wen-ping~ 1．Department of Pathology，Gannan Medical University，Ganzhou 341 000，China；2．Department 0厂 Chemists，The F f Affiliated Hospital，Gannan Medical University；3．Department of Pathology。 People’S Hospital of Jiangxi；4．Department of Microbe，Gannan Medical University Abstract：Objective To study the expression of p53 and its relationship with expression of Ki一67 in the immunology types of diffuse large B-cell lymphoma(DI BCL)．Methods The expression of p53 and Ki一67 in the immunology types of DLBCL and reactive hyperplasia lymphoid node，were detected by MaxVision immunohistochemicalmethod．Results In 60 specimens of DLBCL patients．immunology type：GCB 25 cases，non-GCB 35 cases．GCB 25 cases，the positive rates of p53 were 16．0 ，non-GCB 35 cases，the positive rates of p53 was 45．7 ．GCB 25 cases，Ki-67 were high expression in 4 specimens；non-GCB 35 cases，Ki一67 were high expression in 18 specimens(P0．O1)．Ki一67 were high expression in 12 speci— mens in 20 specimens of DLBCL patients of p53 positive，Ki一67 were high expression in 1 0 specimens in 40 specimens of DLBCL patients of p53 negative．The p53 expression was found significant association with Ki一67 expression．Conclusion The high expression of p53 and Ki一67 were related to non-GCB im— munology type of DLBCL，The low expression of p53 and Ki一67 were related to GCB immunology type of DLBCL Key words：Diffuse large B-cell lym phoma；p53；Ki一67；Immunohistochemistry；Tissue slice 摘 要：目的 探讨p53和Ki一67在DLBCL免疫类型中的表达及相互关系。方法 采用免疫组化 MaxVision法检测p53和Ki一67在DLBCL免疫类型中和反应性增生的淋巴结中的表达。结果 25例 GCB中p53的阳性率为16．0 ，35例non-GCB中p53的阳性率为45．7 ，两者之间P0．01；25例 ’ GCB中Ki-67高表达4例，35例non-GCB中Ki一67高表达 18例，两